Chronic recurrent Vogt-Koyanagi-Harada disease and development of “sunset glow fundus” predict a worse retinal sensitivity​

Journal Article

Al-Muammar​, Ahmed M. Abu El-Asrar; Tariq Al Mudhaiyan; AlHatoon A. Al Najashi; Suhail Hemachandran; Rajab Hariz; Ahmed Mousa; Abdulrahman . 2016

• Publication Work Type: Research
• Magazine \ Newspaper: Ocul Immunol Inflamm.
• Volume Number: 22
• Pages: 1-11

Publication Abstract

Purpose: To investigate prognostic factors for retinal sensitivity assessed by microperimetry in patients with Vogt–Koyanagi–Harada (VKH) disease.

Methods: In total, 34 patients with initial-onset acute disease and 19 patients with chronic recurrent disease were retrospectively evaluated.

Results: The mean follow-up period was 40.4 ± 40.5 months. Sensitivity was significantly worse in eyes with more severe anterior segment inflammation at presentation, as indicated by the presence of mutton-fat keratic precipitates, anterior chamber reaction ≥2+, and posterior synechiae. Chronic recurrent presentation, development of complications, and ‘sunset glow fundus’ were significantly associated with worse sensitivity. Using logistic regression analysis, better sensitivity was significantly associated with initial-onset acute presentation (odds ratio, OR = 6.9; 95% confidence interval, CI = 1.53–9.66).

Conclusions: Chronic recurrent presentation and development of complications and ‘sunset glow fundus’ are associated with a worse sensitivity outcome.

Keywords: Immunomodulatory therapy, microperimetry, outcome, retinal sensitivity, Vogt–Koyanagi–Harada disease