Synthesis and biological evaluation of benzo[d]imidazole derivatives as potential anti-cancer agents

Journal Article

Wang, Hamad M. Alkahtani, Abdullahi Y. Abbas, Shudong . 2012

• رابط المنشور على الويب: http://www.sciencedirect.com/science/article/pii/S0960894X11017690
• المجلة \ الصحيفة: Bioorganic & Medicinal Chemistry Letters
• رقم العدد: 3
• رقم الإصدار السنوي: 22
• الصفحات: من 1317 إلى 1321

مستخلص المنشور

We herein report the synthesis, biological activity and structure–activity relationship of derivatives of 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole and benzo[d]imidazole. A lead compound 6o demonstrates potent anti-proliferative activity and the ability to induce cancer cell apoptosis.