One-pot synthesis of three-dimensional Mn3O4 microcubes for high-level sensitive detection of head and neck cancer drug nimorazole

Journal Article

, Rajaji Umamaheswari , Muthumariappan Akilarasan , Shen-Ming Chen, Yi-Hui Cheng, Veerappan Mani, Sakthivel Kogularasu , Fahad M.A. Al-Hemaid , M. Ajmal Ali , Xiaoheng Liu . 2017

• Publication Work Type: Collaborative Research work
• Publication Online URL: One-pot synthesis of three-dimensional Mn3O4 microcubes for high-level sensitive detection of head and neck cancer drug nimorazo
• Magazine \ Newspaper: Journal of Colloid and Interface Science
• Issue Number: 1 November 2017
• Volume Number: 505
• Pages: Volume 505, 1 November 2017, Pages 1193-1201

Publication Abstract

We described a three-dimensional Mn3O4 microcubes (3D–Mn3O4MCs) synthesised via a facile hydrothermal route for the determination of nimorazole (NMZ), an important drug that used in the treatment of head and neck cancer. The 3D–Mn3O4MCs possess large active area and high conductivity, and 3D–Mn3O4 MCs film modified screen-printed carbon electrode (3D–Mn3O4MCs/SPCE) was fabricated which displayed excellent electrocatalytic ability towards NMZ. Under optimised working conditions, the modified electrode responded linearly to NMZ in the 0.025–8060 µM concentration range and the detection limit was 6 nM. A rapid, sensitive, selective, reproducible, and durable sensor was described. The practical feasibility of the sensor was demonstrated in human serum and NMZ tablet samples. The obtained results revealed the potential real-time applicability of the sensing device in biological analysis and pharmaceutical formulations.