Evaluation of traditional medicinal plant, Cissus setosa Roxb. (Vitaceae) for antiulcer property

Journal Article

, Chinnamaruthu, J., J. Senguttuvan, M.A. Ali, P.Subramaniam, F.M.A. Al-Hemaid . 2017

• Publication Work Type: Collaborative Research work
• Publication Online URL: Evaluation of traditional medicinal plant, Cissus setosa Roxb. (Vitaceae) for antiulcer property
• Magazine \ Newspaper: Saudi Journal of Biological Sciences
• Issue Number: https://doi.org/10.1016/j.sjbs.2017.03.0077
• Volume Number: https://doi.org/10.1016/j.sjbs.2017.03.0077
• Pages: https://doi.org/10.1016/j.sjbs.2017.03.0077

Publication Abstract

Cissus setosa is an indigenous medicinal herb commonly used for the treatment of gastro ulcers. In the
current investigation the aerial methanolic extract of C. setosa was investigated for their antiulcer activity
using pylorus ligation and ethanol in experimental rats. The extract was administered at the doses of 200
and 400 mg/kg b.w. orally for 3 days. However, higher dose of the extract subsequently reduced gastric
ulcer induced aberrations by pylorus ligation (70.05%) and ethanol (78.16%) as judged by their altered
biochemical parameters such as free acidity, total acidity, total carbohydrate, total protein and pepsin
activity. Furthermore, macroscopic examination of rat’s stomach also showed that the pretreatment with
methanolic extract notably lowered the pylorus ligation and ethanol induced ulcers. As perceived in the
present study, evidently, our findings basically supports the potency of the methanol extracts of C. setosa
to treat gastrointestinal related disorders, thus lends pharmacological credence to the suggested folklore
use.