Natural Products Separation Techniques (PHG 515)

The basic goal of this course is to provide the student with the theory and practice of the basic and advance methods used in extraction, separation and purification of natural products. This includes the chromatographic techniques, such as GC, HPLC as well as chiral separations, and non-chromatographic techniques, like solid state, liquid-solid and liquid-liquid extraction, solvent partitioning, countercurrent distribution, sublimation, electrophoresis, precipitation and crystallization. Additionally, the course will discuss the challenges of isolating natural compounds from marine organisms, and the stability of isolated natural products. At the end of the course, student will be able to select and apply the suitable methods of extraction, manipulate and isolate the different types of compounds with various complexities.