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Dina Mahmoud Ahmed Hasanin

Associate Professor

Faculty member

كلية العلوم
Building 5,3rd floor,office 114
المنشورات
مقال فى مجلة
2020

Nephroprotective effects of chlorogenic acid against sodium arsenite-induced oxidative stress, inflammation, and apoptosis

El-khadragy, Wafa A AL-Megrin,a Dina M Metwally,b,c Ola A Habotta,d Hatem K Amin,e Ahmed E Abdel Moneimf and Manal . 2020

BACKGROUND: Chronic exposure to arsenic (As) leads to serious renal disorders. Chlorogenic acid (CGA), a phenolic compound, has several well known physiological benefits, including antioxidant and anti-inflammatory activities. The present study investigated the potential renoprotective effects of CGA on sodium arsenite (NaAsO2)-induced kidney damage in mice. The mice were randomly allocated into five groups to receive daily treatment with CGA (200 mg kg−1 ), NaAsO2 (5 mg kg−1 ), NaAsO2 + CGA (100 mg kg−1 ), NaAsO2 + CGA (200 mg kg−1 ), or a control for 28 days. RESULTS: In the NaAsO2-treated group, NaAsO2 induced significant renal dysfunction, oxidative damage, inflammation, and apoptosis, as demonstrated by marked increases in urea and creatinine levels accompanied by a decrease in the kidney index. Considerable increases in malondialdehyde and nitric oxide levels and parallel decreases in various antioxidant markers (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione) levels were also detected in the renal tissues of NaAsO2-treated mice. NaAsO2 exposure was associated with marked increases in renal inflammatory markers (interleukin-1⊎ and tumor necrosis factor-⊍) and apoptosis indicators including Bax and caspase-3 levels contaminant, with a marked decrease in Bcl-2, an anti-apoptotic protein, in the NaAsO2-treated group compared with the control group. However, pretreatment with CGA substantially mitigated the renal injury and dysfunction associated with NaAsO2 exposure by reducing tissue inflammation and apoptosis and improving the antioxidant status. The CGA pretreatment also alleviated the NaAsO2- induced histological alterations in renal tissues. CONCLUSION: Taken together, our results suggest the efficacy of CGA in alleviating As-mediated renal tissue damage. 

مجلة/صحيفة
J Sci Food Agric
مزيد من المنشورات
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Malaria is an important health problem in subtropical and tropical areas around the world. Infection with protozoan parasites of the Plasmodium genus, which grow inside host erythrocytes, causes…

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Sarcocystis spp. are intracellular protozoan parasites with an intermediate-definitive host life cycle based on a prey–predator relationship. Sarcocystis infection is common among different…

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Arsenic is a potent neurotoxic xenobiotic found in drinking water, and food. Chlorogenic acid (CGA), an abundant polyphenol in coffee, potentially has a wide range of therapeutic benefits.

بواسطة Dina M. Metwallya,b,c , Reem A. Alajmia , Manal F. El-Khadragyd,e,⁎ , Hany M. Yehiaf,g , Wafa A. AL-Megrind , Ahmed M.A. Akabawyh , Hatem K. Aminh , Ahmed E. Abdel Moneim
2020