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Dr. rer. nat Elsayed Ahmed Elsayed

Associate Professor

Faculty Staff Member

كلية العلوم
Building 5, AB107
المنشورات
مقال فى مجلة
2016

In vitro assessment of anticancer properties of Moringa peregrina essential seed oil on different cell lines

M, Elsayed EA, Sharaf-Eldin MA, El-Enshasy HA and Wadaan . 2016

Moringa peregrina belongs to the Moringaceae family and is native to the western part of Saudi Arabia and the eastern part of Egypt, from where it has been transferred to tropical and subtropical countries. The Moringa trees are highly appreciated for their nutritional and medicinal properties. In the past two decades, research has focused on investigating different parts of Moringa as a source for anticancer preparations. However, M. peregrina extracts were only evaluated for their antioxidant and anti-inflammatory activities, and the literature contains few (or no) information about the cytotoxic properties reported for M. peregrina seed oil. Accordingly, the current work aimed to evaluate the potential anti-proliferative properties of essential oil obtained from M. peregrina and its effects on various cell types. Different cell lines were exposed to increasing concentrations from the seed oil (0.15 to 1000 μg/mL) for 24h, and cell toxicity was evaluated. Results revealed that all cell lines under investigation were significantly affected depending on the used oil concentration. Furthermore, cell lines showed different response to the treatment with oil according to cell type. Additionally, HepG2 and HeLa cells showed the highest response to the applied essential oil, followed by MCF-7, CACO-2 and L929, where the toxicity percentages at the maximal oil doses recorded 75.82, 75.35, 67.89, 57.50 and 53.43%, respectively. The IC50 value obtained for HeLa cells was 366.3 μg/mL, and increased by 1.7- and 2.0-fold for HepG2 and CACO-2 cells, respectively. The present results suggest that essential oil isolated from M. peregrina seeds has potential cytotoxic properties against different cancer cell lines

رقم المجلد
48
رقم الانشاء
3
مجلة/صحيفة
Paksitan J. Zool
الصفحات
853-859
مزيد من المنشورات
publications

Background: Pectinase enzymes present a high priced category of microbial enzymes with many potential applications in various food and oil industries and an estimated market share of $ 41.4…

بواسطة El Enshasy, Elsayed EA, Suhaimi N, MalekRA, Esawy M
2018
publications

A series of azocompounds containing methyl salicylate 4a–k and 1-naphthyl moiety 6–8 was synthesized and tested as anticancer
agents. Nitrosation of methyl 5-amino-2-hydroxybenzoate or 1-…

بواسطة El-Naggar M, El-Shorbagi A-N, El-Naggar D, Amr AE, Al-Omar M, Elsayed EA
2018
publications

Invertase (β-D-fructofuranoside fructohydrolase; EC 3.2.1.26) constitutes an improtant microbial enzyme with wide applications in differnt food and pharmaceutical sectors. The present work used…

بواسطة Elsayed EA, El Enshasy HA
2018