.Protective Effect of Aspirin on γ Radiation Induced Chromosomal Aberrations in Swiss Albino Male Mice

Journal Article

, Marowa Al Mathkour, . 2014

• نوع عمل المنشور: ورقة بحثية
• المجلة \ الصحيفة: Research Journal of Radiology
• رقم العدد: 1
• رقم الإصدار السنوي: 1
• الصفحات: 1-6

مستخلص المنشور

The objective of this investigation was to develop and evaluate potential radio-protective of Aspirin through assessment of structural chromosomal aberrations (CA) induced by γ-ray in Swiss Albino male mice. Aspirin at doses of 0.5, 5 and 50 mg/kg was intra-peritoneal injected to Swiss Albino male mice 72 hours before 2Gy or 4Gy doses of γ radiation exposure. Following mice exposing to 2Gy γ radiation, great structural chromosomal aberrations occurred. With injection of 0.5mg/kg with 2Gy or 4Gy radiation, the chromosomal aberrations, were significantly reduced in all structural aberrations (P<0.0001). With the increase of Aspirin doses (5mg/kg and 50 mg/kg) the radio-protective effect still significantly valid (P<0.05), but relatively lower than radio-protective provided with low dose (0.5mg/kg). Therefore, the radio-protective role of Aspirin was found to be statistically significant. The present study suggests that Aspirin pretreatment provides protection against radiation induced structural chromosomal aberrations.