A Role of Semaphorin-3E in Regulating Natural Killer Cell Migration in Natural Killer Cell – Dendritic Cell Crosstalk
, Abdulaziz Alamri . 2016
Semaphorin-3E (Sema-3E) is a member of the Semaphorin family that plays important regulatory roles in nervous and immune system. Natural Killer (NK) and dendritic cells (DC) are immune cell types that mediate/shape innate and adaptive immunity. The role of Sema-3E in regulating NK cell biology has not been reported.
first, we demonstrated that IL-2 activated NK cells expressed Sema-3E receptors on cell surface. we compared NK migratory responses towards conditioned media of DC (immature, LPS- or Poly I:C stimulated) derived from Sema-3E+/+ or Sema-3E-/- mice. Of interest, we observed that activated NK cells exhibited a two-fold increase in the migrations toward immature Sema-3E -/- DC conditioned medium when compared to that of the immature Sema-3E+/+ DC. Our work revealed a novel role of Sema-3E in limiting NK-cell migrations toward immature DC in NK-DC crosstalk. Future delineations of the impact and signaling of the Sema-3E pathway in NK-DC crosstalk may support novel development of immunotherapy for cancer and infectious diseases.
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Abstract
Abstract
Background: Ovarian cancer leads to devastating outcomes, and its treatment is highly
challenging. At present, there is a lack of clinical symptoms and well-known sensitivity…