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فهد عبده أحمد المخلافي

Associate Professor

قسم علم الحيوان

كلية العلوم
مبنى 5 الدور الأرضي رقم المكتب أب 75/1
المنشورات
مقال فى مجلة
2016

Biological activity of Xanthium strumarium seed extracts on different cancer cell lines and Aedes caspius, Culex pipiens (Diptera: Culicidae)

Effects of methanol extracts of Xanthium strumarium on different cancer cell lines and on
the mortality rates of Aedes caspius, Culex pipiens (Diptera: Culicidae) were investigated. Among
the cell lines tested, the Jurkat cell line was the most sensitive to the methanol extract and ethyl acetate
fraction, with reported LC50 values of 50.18 and 48.73 lg/ml respectively. Conversely, methanol
extracts were not that toxic to the A549 cell line though the toxicity increased on further purification.
The percentage of growth inhibition was dose dependent for the methanol extract and ethyl
acetate fraction. The ethyl acetate fraction showed higher toxicity to all cell lines tested when compared
to the methanol extract. The results showed that methanol extracts of plant seeds caused
100% mortality of mosquito larvae at a concentration of 1000 lg/ml after 24 h of treatment. The
LC50 and LC90 values of X. strumarium were found to be 531.07 and 905.95 lg/ml against Ae. caspius
and 502.32 and 867.63 lg/ml against Cx. Pipiens, respectively. From the investigations, it was
concluded that the crude extract of X. strumarium showed a weak potential for controlling the larval
instars of Ae. caspius and Cx. pipiens. However, on further purification the extract lost the larvicidal
activity. The ethyl acetate fraction showed higher toxicity to all cell lines tested when compared to
the methanol extract. The ethyl acetate fraction investigated in this study appears to have a weak
larvicidal activity but a promising cytotoxic activity. Future studies will include purification andinvestigation in further detail of the action of X. strumarium on Cancer Cell Lines and mosquitoes.
2016 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is
an open access article under theCCBY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/).

رقم المجلد
817-821
مجلة/صحيفة
Saudi J Biol Sci
الصفحات
817-821
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