Research Interests
The end goal of our research is the development of targeted drug delivery through the detailed investigation of immunology. Specifically, the immunological aspects of autoimmune and neuroimmunological disorders are a central interest within our laboratory. We utilize our in-depth understanding of flow cytometry in the analysis of various aspects of immunology and for the identification of potential drug targets.  In order to further understanding of several immune diseases we utilize models of arthritis, lung inflammation, acute and chronic stress models in experiments to assess the status of expression of colony stimulation factors, pro and anti-inflammatory mediators, cell surface markers (CD4, CD8, CD25, GITR, OX-40), cytokines (Th1/Th2 and Th17), TLRs, chemokines and their receptors, adhesion and costimulatory molecules, and transcription factors (Foxp3, T-bet, RORγt, GATA-3, NF-κB and JAK/STAT) pathways using. With regard to the autoimmune disease, rheumatoid arthritis (RA), our laboratory is focused on inflammation immunology in general, and specifically on the role of T cell homeostasis in this debilitating joint disorder. Specifically, we have investigated the effects of an agonist and an antagonist to the histamine 4 receptor, several PARP inhibitors, JAK/STAT3 inhibitors, and a tyrosine kinase inhibitor in different animal diseases models. The results of this work have been published in several peer-reviewed journals. In addition, we have studied the immunological imbalance in autistic children in attempts to understand the underlying pathophysiology of this diseasse and to potentially open new avenues for treatment. Furthermore, we have also evaluated the role of Th1/Th2/Th17 and Treg-related transcription factors in both children with autistic disorders and the BTBR T+tf/J animal model.