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Fowad Khurshid فؤاد خورشيد

Lecturer

Lecturer at Department of Clinical Pharmacy محاضر بقسم الصيدلة الاكلينيكية

كلية الصيدلة
College of Pharmacy, Department of Clinical Pharmacy مكتب : كلية الصيدلة-قسم الصيدلة الاكلينيكية-الدور الاول
المنشورات
مقال فى مجلة
2017

Effect of herb-drug interactions of Bacopa monnieri Linn. (Brahmi) formulation on the pharmacokinetics of amitriptyline in rats

Alsultan, Fowad Khurshid, Jeyabalan Govindasamy, Habibullah Khalilullah, Mohammed Shivli Nomani, Mudassar Shahid, Md Ruhal Ain, Mohammad Sultan . 2017

Interactions between herbs and drugs may increase or decrease the pharmacological or toxicological effects of either component. Experimental data on the pharmacokinetic interactions between herbal products and drugs are limited. This study attempted to investigate the effect of Bacopa monnieri Linn. (Brahmi) formulation on the pharmacokinetics of amitriptyline in rats. In this study, rats were randomly divided into two groups (n = 6 each) which were served as a control (amitriptyline alone) and treatment group (amitriptyline with B. monnieri), respectively. Rats in the treatment group received B. monnieri (31 mg/kg/day) whereas the control group received normal saline by oral gavage for seven days before a single intragastric administration of 25 mg/kg amitriptyline. Plasma concentrations of amitriptyline were measured up to 24 h after its administration by a developed and validated high-performance liquid chromatography method. Pretreatment with B. monnieri produced a significant increase in the maximum plasma concentration (Cmax), area under the curve (AUC0-t) and elimination half-life (t1/2) of amitriptyline by 16.8%, 26.5%, and 15.5%, respectively, compared to amitriptyline alone. Moreover, oral clearance and volume of distribution (Vss) were decreased by 26.2% and 15.5% respectively. This study concluded that B.monnieri significantly enhanced the oral bioavailability of amitriptyline in rats. 

 

رقم المجلد
53
رقم الانشاء
4
مجلة/صحيفة
Brazilian Journal of Pharmaceutical Sciences
الصفحات
e17072
مزيد من المنشورات
publications

Purpose: This study aimed to explore the physician’s knowledge and identify the perceived barriers that prevent family medicine physicians from engaging in deprescribing among older  patients.

بواسطة Maha M Alrasheed, Tariq M Alhawassi, Alanoud Alanazi, Nouf Aloudah, Fowad Khurshid, Mohammed Alsultan;
2018
publications

SUMMARY. This study evaluates the effect of Centella asiatica formulation on the pharmacokinetics of amitriptyline in rats. In this study, rats were randomly divided into two groups (n = 6 each)…

بواسطة Fowad KHURSHID, Jeyabalan GOVINDASAMY, Habibullah KHALILULLAH, Mohammed Shivli NOMANI, Mudassar SHAHID , Md Ruhal AIN & Mohammad S. ALSULTAN
2018
publications

Interactions between herbs and drugs may increase or decrease the pharmacological or toxicological effects of either component. Experimental data on the pharmacokinetic interactions between herbal…

بواسطة Fowad Khurshid, Jeyabalan Govindasamy, Habibullah Khalilullah, Mohammed Shivli Nomani, Mudassar Shahid, Md Ruhal Ain, Mohammad Sultan Alsultan
2017