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د. غادة الحمود | Dr. Gadah Al-Hamoud

Assistant Professor

College of Pharmacy, KSU

كلية الصيدلة
College of Pharmacy (Female Campus), Building 8, Floor 2, Office NO 87
المنشورات
مقال فى مجلة
2019
تم النشر فى:

Lasianosides A–E: New Iridoid Glucosides from the Leaves of Lasianthus verticillatus (Lour.) Merr. and Their Antioxidant Activity

Al-Hamoud, Gadah Abdulaziz . 2019

Lasianthus trichophlebus; Rubiaceae; DPPH; radical scavenging activity; cytotoxicity

The genus Lasianthus (Rubiaceae) consists of approximately 180 species, of which the greatest species diversity is found in tropical Asia. Some of the Lasianthus species have been used in folk medicine to treat tinnitus, arthritis, fever, and bleeding. Lasianthus verticillatus (Lour.) Merr. (Syn. Lasianthus trichophlebus auct. non Hemsl.) is a shrub, branchlets terete about 1.5–3 m in height. This paper studies the chemical composition of the leaves of L. verticillatus for the first time, which resulted in the isolation of five undescribed iridoid glucosides, lasianosides A–E (15), together with three known compounds (68). The undescribed structures of isolated compounds (15) were characterized by physical and spectroscopic data analyses, including one-dimensional (1D) and two-dimensional (2D) NMR, IR, UV, and high-resolution electrospray ionization mass spectra (HR-ESI-MS). Furthermore, the electronic circular dichroism data determined the absolute configurations of the new compounds. The free radical scavenging properties of isolated compounds was assessed by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, and their cytotoxicity was assessed toward human lung cancer cell line A549 by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Among the isolated compounds, 3 and 4 displayed potent radical scavenging activities with IC50 values of 30.2 ± 1.8 and 32.0 ± 1.2 µM, which were comparable to that of Trolox (29.2 ± 0.39 µM), respectively, while 5 possessed moderate activity with an IC50 value of 46.4 ± 2.3 µM. None of the isolated compounds exerted cytotoxicity against human cell line A549. As a result, lasianosides C, D, and E have the potential to be non-toxic safe antioxidant agents.

نوع عمل المنشور
دكتوراه
رقم المجلد
21
رقم الانشاء
24
مجلة/صحيفة
Molecules
الصفحات
1-14
مزيد من المنشورات
publications

The genus Lasianthus (Rubiaceae) consists of approximately 180 species, of which the greatest species diversity is found in tropical Asia. Some of the Lasianthus species have…

بواسطة Gadah Abdulaziz Al-Hamoud, Raha Saud Orfali, Shagufta Perveen, Kenta Mizuno, Yoshio Takeda, Tatsuo Nehira, Kazuma Masuda, Sachiko Sugimoto, Yoshi Yamano, Hideaki Otsuka, Katsuyoshi Matsunami
2019
publications

Cadaba rotundifolia (Forssk.) (family: Capparaceae; common name: Qadab) is one of four species that grow in the Red Sea costal region in the Kingdom of Saudi Arabia. The roots and leaves…

بواسطة Gadah Abdulaziz Al-Hamoud, Raha Saud Orfali, Sachiko Sugimoto, Yoshi Yamano, Nafee Alothyqi, Ali Mohammed Alzahrani , Katsuyoshi Matsunami
2019
publications

The naphthalene glycosidecurviflorside [1,5-dihydroxy-8-methoxynaphthalene-2-O-β-D-xylopyranoside] (3) and the flavanol curviflorin [(+)-catechin-7-O-3″,4″-dihydroxybenzoate] (4), along with two…

بواسطة Nawal M. Al Musayeib, Sabrin R.M. Ibrahim, Musarat Amina, Gadah A. Al-Hamoud , Gamal A. Mohamed
2017