Nanostructural Changes in the Cell Membrane of Gamma-Irradiated Red Blood Cells
AlZahrani, Khalid . 2016
The effect of gamma radiation on the ultrastructure
of the cell membranes of red blood cells has been
probed using a powerful tool, namely, atomic force
microscopy. We used mice erythrocytes as a model. Blood
samples withdrawn from mice were gamma-irradiated
using a 60Co source unit with doses of 10,15,20,25 and
30 Gy. Structural changes appeared in the form of nanoscale
potholes, depressions and alterations of the cell
membrane roughness. The roughness of the cell membrane
increased dramatically with increasing doses, although at
10 Gy, the cell membrane roughness was less than that of
normal red blood cells (controls). Therefore, such modifications
at the nano-scale level may affect the biophysical
properties of membranes, resulting in impairment of their
function.
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