Mitigation of Acetamiprid – Induced Renotoxicity by Natural Antioxidants via the Regulation of ICAM, NF-kB and TLR 4 pathways
A., Ahlam Alhusainia, Laila M Faddaa, Hanaa M Alib,c, Iman H Hasana, Rehab A Alia, Enas Zakaria . 2019
Acetamiprid (ACMP) is a member of the neonicotinoid group of insecticides. It is extensively used worldwide. The misuse of ACMP creates danger hazards to human and animal. Methods: ACMP induced renal damage evidenced by an increase in kidney injury biomarkers. So the goal of this work is to clarify the reno protective effect of Quercetin(Qrctn) and/or Nano-glutathione (N- Gluta) solely or in combination to counterbalance the danger effect of ACMP. All treatments with the previous agents were coadministered orally with ACMP for one month.. Results: ACMP ingestion caused a significant rise in serum creatinin, urea, and uric acid, TNF α along with renal cystatin C, lipid peroxidation and nitric oxide with the concomitant decline in the levels of reduced glutathione and IL-10 levels. Protein expression of ICAM was upregulated as well as mRNA expression of NF-kB while mRNA expression of Nrf2 was down-regulated. Immune histochemistry of TLR 4
revealed strong Immune reaction. The administration of Qrctn or N- Gluta either individually or together modulated all the preceding aforementioned parameters. Conclusion; Fascinatingly Qrctn and N- Gluta combination was the most powerful regimen to frustrate ACMP reno-toxicity and may be deliberate as a hopeful applicant for renal thera.
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Hypoxia may lead to inflammatory responses by numerous signaling pathways. This investigation intended to inspect the defensive role of Quercetin (Quer) and/ or Melatonin (Mel) against reno…