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Luluah Alhusain

Assistant Professor

Faculty

علوم الحاسب والمعلومات
6T75
المنشورات
مقال فى مجلة
2018

Nonparametric approaches for population structure analysis

Alhusain, Luluah . 2018

The analysis of population structure has many applications in medical and population genetic research. Such analysis is used to provide clear insight into the underlying genetic population substructure and is a crucial prerequisite for any analysis of genetic data. The analysis involves grouping individuals into subpopulations based on shared genetic variations. The most widely used markers to study the variation of DNA sequences between populations are single nucleotide polymorphisms. Data preprocessing is a necessary step to assess the quality of the data and to determine which markers or individuals can reasonably be included in the analysis. After preprocessing, several methods can be utilized to uncover population substructure, which can be categorized into two broad approaches: parametric and nonparametric. Parametric approaches use statistical models to infer population structure and assign individuals into subpopulations. However, these approaches suffer from many drawbacks that make them impractical for large datasets. In contrast, nonparametric approaches do not suffer from these drawbacks, making them more viable than parametric approaches for analyzing large datasets. Consequently, nonparametric approaches are increasingly used to reveal population substructure. Thus, this paper reviews and discusses the nonparametric approaches that are available for population structure analysis along with some implications to resolve challenges.

رقم المجلد
12
مزيد من المنشورات
publications

Pervasive sensing has opened up new opportunities for measuring our feelings and understanding our behavior by monitoring our affective states while mobile.

بواسطة Luluah Alhusain
2015
publications

The analysis of population structure has many applications in medical and population genetic research. Such analysis is used to provide clear insight into the underlying genetic population…

بواسطة Luluah Alhusain
2018
publications

Background

بواسطة Luluah Alhusain, Alaaeldin M. Hafez
2017