Switching from (R)- to (S)-selective chemoenzymatic DKR of amines involving sulfanyl radical-mediated racemization

Journal Article

ElBlidi, Lahssen . 2010

• Publication Online URL: Switching from (R)- to (S)-selective chemoenzymatic DKR of amines involving sulfanyl radical-mediated racemization
• Tags: Chemoenzymatic dynamic kinetic resolution (DKR), amines, sulfanyl radical-mediated racemization
• Magazine \ Newspaper: Organic & Biomolecular Chemistry
• Issue Number: 18
• Volume Number: 8
• Pages: 4165-4168

Publication Abstract

Chemoenzymatic dynamic kinetic resolution (DKR) of amines involving sulfanyl radical-induced racemization happened to be the very first switchable DKR process allowing the synthesis of either (R)- or (S)-amides, in good yield and high enantiomeric excess, depending on the nature of the enzyme; the different steps of the development of (S)-selective DKR are discussed.