المنشورات و المؤلفات
A thalidomide analog, (4‐(1,3‐dioxo‐1,3‐dihydro‐2H‐isoindol‐2‐yl)‐N′‐[(4‐ethoxyphenyl)
methylidene] benzohydrazide), has been identified as a promising broad‐spectrum anti‐inflammatory
agent in previous study. In this study, a sensitive and...
A new series of 3,4,5-trimethoxyphenyl bearing
pyrazole (4a–g) and pyrazolo[3,4-d]pyridazine (5a–g)
scaffolds were synthesized in good yield. The newly synthesized
compounds were characterized on the basis of
elemental and spectroscopic analyses....
New pyrazoline derivatives were synthesized via the reaction of chalcones with cyclohexyl/phenyl
thiosemicarbazide in presence of ethanol and acetic acid. All the compounds were confirmed by FT IR,
1H NMR, 13C NMR and MS spectral data. The compounds...
A series of Schiff base derivatives 4a-k were synthesized from 4-amino-3-(4-pyridyl)-5-mercapto-
4H-1,2,4-triazole 3 as starting materials by using microwave irradiation technique. The synthesized
compounds were fully characterized by NMR, FT-IR,...
Solubility of dihydropyrimidine derivative 4-(4-ethoxyphenyl)-5-(3,4,5 trimethoxybenzoyl)-3,4-
dihydropyrimidine-2(1H) one (DHP-5), a novel anticancer drug, was experimentally measured in PEG-
400 + water binary solvent mixtures over a temperatures...
Novel 4-(4-substituted phenyl)-5-(3,4,5-trimethoxy/3,4-dimethoxy)-benzoyl-3,4-
dihydropyrimidine-2(1H)-one/thione derivatives (DHP 1–9) were designed, synthesized,
characterized and evaluated for antitumor activity against cancer stem cells. The...
Side population (SP) cells mediate chemoresistance in leukemia. However, chemical inhibition
approach to target SP cells has been poorly studied. Herein, we report the discovery of isatin derivatives
of nicotinic acid amide as potent side population...
The reaction of 2-isonicotinoyl-N-cyclohexyl/
arylhydrazinecarbothioamide (2a–r) with sodium hydroxide,
in each case, a single product was obtained. The
structures of the compounds were confirmed on the basis of
their elemental analysis and spectral...
In the present study, various nanoemulsion formulations of carvone Schiff base of isoniazid (CSB-INH) were
developed by aqueous phase titration method in order to evaluate its anticancer potential. Developed
nanoemulsions of CSB-INH were...
In this study, a fast UHPLC-MS/MS method was developed and validated for the determination of a novel potent
carvone Schiff base of isoniazid (CSB-INH) in rat plasma using carbamazepine as an internal standard (IS). After a single-step
protein...
Lead derivatives of 2-cyclohexyl-N-[(Z)-(3-methoxyphenyl/3-hydroxyphenyl)
methylidene]hydrazinecarbothioamides 1–18 were synthesized, characterized and evaluated
in vitro against HER-2 overexpressed breast cancer cell line SKBr-3. All the compounds...
N-Arylphthalimides (1−10P) derived from thalidomide
by insertion of hydrophobic groups were evaluated for
anti-inflammatory activity, and (4-(1,3-dioxo-1,3-dihydro-2Hisoindol-
2-yl)-N′-[(4-ethoxyphenyl)methylidene]benzohydrazide
6P was identified as...
tA simple and sensitive UPLC–MS/MS assay was developed and validated for rapid determination ofthiosemicarbazide derivative of isoniazid (TSC-INH), a potent anti-candidal agent in rat plasma, tissues,urine and feces. All biological samples were...
The present approach enumerates the effectiveness of tuftsin tagged nano-liposome for the cytosolic
transport of 2,6-di-isopropylphenol-linolenic acid conjugate against liver cancer in mice. Initially, the
conjugate in its free form was examined for...