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Mohammad A. Alfuhaily, PhD د. محمد عبدالمحسن الفحيلي

Associate Professor

College of Applied Medical Sciences, Department of Clinical Laboratory Sciences

كلية العلوم الطبية التطبيقية
Building 24, Office 2299
المنشورات
مقال فى مجلة

List of publications

Publications: (*) Denotes corresponding author.

            (1) Original Articles/Reviews:

(1) Yoon DS, Alfhili MA, Friend K, Lee MH. MPK-1/ERK regulatory network controls the number of sperm by regulating timing of sperm-oocyte switch in C. elegans germline. Biochem Biophys Res Commun. 2017 Sep 30;491(4):1077-1082. doi: 10.1016/j.bbrc.2017.08.014. Epub 2017 Aug 3.

(2) Yoon DS, Choi Y, Cha DS, Zhang P, Choi SM, Alfhili MA, Polli JR, Pendergrass D, Taki FA, Kapalavavi B, Pan X, Zhang B, Blackwell TK, Lee JW, Lee MH. Triclosan Disrupts SKN-1/Nrf2-Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells. Sci Rep. 2017 Oct 3;7(1):12592. doi: 10.1038/s41598-017-12719-3.

(3) Yoon DS, Cha DS, Alfhili MA, Keiper BD, Lee MH. Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline. FEBS J. 2018 Jul;285(14):2590-2604. doi: 10.1111/febs.14512. Epub 2018 May 28.

(4) Alfhili MA, Yoon DS, Faten TA, Francis JA, Cha DS, Zhang B, Pan X, Lee MH. Non-Ionic Surfactants Antagonize Toxicity of Potential Phenolic Endocrine-Disrupting Chemicals, Including Triclosan in Caenorhabditis elegans. Mol Cells. 2018 Dec 31;41(12):1052-1060. Epub 2018 Nov 14.

(5) Alfhili MA, Nkany MB, Weidner DA, Lee MH. Stimulation of eryptosis by broad-spectrum insect repellent N,N-Diethyl-3-methylbenzamide (DEET). Toxicol Appl Pharmacol. 2019 Mar 14; 370:36-43. doi: 10.1016/j.taap.2019.03.011. Epub 2019 Mar 14.

(6) Hussein HAM, Alfhili MA, Pakala P, Simon S, McCubrey JA, Akula SM. miRNAs and their roles in KSHV pathogensis. Virus Res. 2019 Jun; 266:15-24. doi: 10.1016/j.virusres.2019.03.024. Epub 2019 Apr 2.

(7) Alfhili MA, Lee MH. Triclosan: an update on biochemical and molecular mechanisms. Oxid Med Cell Longev. 2019 May 2; 2019:1607304. doi: 10.1155/2019/1607304. eCollection 2019.

(8) Alfhili MA, Weidner DA, Lee MH. Disruption of erythrocyte membrane asymmetry by triclosan is preceded by calcium dysregulation and p38 MAPK and RIP1 stimulation. Chemosphere. 2019 Aug;229:103-111. doi: 10.1016/j.chemosphere.2019.04.211. Epub 2019 May 4.

(9) Dera A, Rajagopalan P, Alfhili MA, Ahmed I. Thymoquinone attenuates oxidative stress of kidney mitochondria and exerts nephroprotective effects in oxonic acid-induced hyperuricemia rats. BioFactors. 2020 Mar;46(2):292-300. doi: 10.1002/biof.1590. Epub 2019 Nov 23.

(10) Park Y, O'Rourke S, Taki FA, Alfhili MA, Lee MH. Dose-Dependent Effects of GLD-2 and GLD-1 on Germline Differentiation and Dedifferentiation in the Absence of PUF-8. Front Cell Dev Biol. 2020 Jan 24; 8:5. doi: 10.3389/fcell.2020.00005. eCollection 2020.

(11) Dera A, Rajagopalan P, Ahmed I, Alfhili M, Alsughayyir J, Chandramoorthy HC. Thymoquinone attenuates IgE-mediated allergic response via pi3k-Akt-NFκB pathway and upregulation of the Nrf2-HO1 axisJ Food Biochem. 2020 Jun;44(6):e13216. doi: 10.1111/jfbc.13216. Epub 2020 Mar 24.

(12) Alamri H, Alahmari B, Altayar B, Alquraini S, Aldriwesh M, Karar T, Abdulfattah M, Alhawiti N, Akiel M, Alsughayyir J, and Alfhili MA*. Serum TSH and 25(OH)D in Saudi thyroid cancer patients: a retrospective, cross-sectional studyIntl J Curr Res. 2020 Mar 24; 10840-10844. doi: 10.24941/ijcr.38036.03.2020. Epub 2020 Mar 24.

(13) Alfhili MA, Alsughayyir J, McCubrey J, Akula SM. GSK-3-associated signaling is crucial to virus infection of cells. Biochim Biophys Acta Mol Cell Res. 2020 Oct;1867(10):118767. doi: 10.1016/j.bbamcr.2020.118767. Epub 2020 Jun 6.

(14) Dera AA, Al Fayi M, Otifi H, Alshyarba M, Alfhili M, Rajagopalan P. Thymoquinone (Tq) protects necroptosis induced by autophagy/mitophagy-dependent oxidative stress in human bronchial epithelial cells exposed to cigarette smoke extract (CSE)J Food Biochem. 2020 Sep;44(9):e13366. doi: 10.1111/jfbc.13366. Epub 2020 Jul 7.

(15) Park Y, Gaddy MA, Alfhili MA*, Lee MH. The teratogenic effect of Triclosan on embryogenesis is attenuated by Tween 20 in Caenorhabditis elegans. MicroPubl Biol. 2020 Jul 23;2020:10.17912/micropub.biology.000282. doi: 10.17912/micropub.biology.000282.

(16) Akiel M, Mohamud M, Adriwesh M, Alamri H, Alhawiti N, Alfhili MA. Translation and cross-cultural validation of the non-invasive prenatal testing questionnaire into Arabic. Saudi Med J. 2020 Sep;41(9):999-1010. doi: 10.15537/smj.2020.9.25272.

(17) Sultan SA, Khawaji MH, Alsughayyir J, Alfhili MA, Alamri HS, Alrefaie BM. Antileukemic activity of sulfoxide nutraceutical allicin against THP-1 cells is associated with premature phosphatidylserine exposure in human erythrocytes. Saudi J Biol Sci. 2020 Dec;27(12):3376-3384. doi: 10.1016/j.sjbs.2020.09.005. Epub 2020 Sep 8.

(18) Oh S, Bae W, Alfhili MA, Lee MH, Koo HS. Nucleotide Excision Repair and Translesion Synthesis are More Critical Than the Fanconi Anemia Pathway in Interstrand Crosslinks Repair in Caenorhabditis elegans. Biochemistry. 2020 Sep 29;59(38):3554-3561. doi: 10.1021/acs.biochem.0c00719. Epub 2020 Sep 18.

(19) Alamri HS, Alsughayyir J, Akiel M, Al-Sheikh YA, Basudan AM, Dera A, Basuwdan AM, Barhoumi T, Alfhili MA*. Stimulation of calcium influx and CK1α by NF-κB antagonist [6]-Gingerol reprograms red blood cell longevity. J Food Biochem. 2021 Jan;45(1):e13545. doi: 10.1111/jfbc.13545. Epub 2020 Nov 3.

(20) Alfhili MA, Hussein HH, Lee MH, Park Y, Akula SM. Triclosan induces apoptosis in Burkitt lymphoma-derived BJAB cells through caspase and JNK/MAPK pathways. Apoptosis. 2021 Feb;26(1-2):96-110. doi: 10.1007/s10495-020-01650-0. Epub 2021 Jan 2.

(21) Akiel M, Alsughayyir J, Basudan MA, Alarmi HS, Dera A, Barhoumi T, Al Subayyil AM, Basmaeil YS, Aldakheel FM, Alakeel R, Ghneim HK, Al-Sheikh YA, Alraey Y, Asiri S, Alfhili MA*. Physcion Induces Hemolysis and Premature Phosphatidylserine Externalization in Human Erythrocytes. Biol Pharm Bull. 2021 Mar 1;44(3):372-378. doi: 10.1248/bpb.b20-00744. Epub 2021 Jan 9.

(22) Dera A, Ahmad I, Rajagopalan P, Al Shahrani M, Saif A, Alshahrani MY, Alraey Y, Alamri AM, Alasmari S, Makkawi M, Alkhathami A, Zaman G, Hakami A, Alhefzi R, Alfhili MA. Synergistic efficacies of thymoquinone and standard antibiotics against multidrug-resistant isolates. Saudi Med J. 2021 Feb;42(2):196-204. doi: 10.15537/smj.2021.2.25706.

(23) Alfhili MA*, Alsughayyir J, Basudan AM. Reprogramming of erythrocyte lifespan by NFκB-TNFα naphthoquinone antagonist β-lapachone is regulated by calcium overload and CK1α. J Food Biochem. 2021 Apr;45(4):e13710. doi: 10.1111/jfbc.13710. Epub 2021 Mar 22.

(24) Gaddy MA, Kuang S, Alfhili MA, Lee MH. The soma-germline communication: Implications for somatic and reproductive aging. BMB Rep. 2021 May;54(5):253-259.

(25) Alfhili MA*, Alsughayyir J, Basudan AM. Epidemic dropsy toxin, sanguinarine chloride, stimulates sucrose-sensitive hemolysis and breakdown of membrane phospholipid asymmetry in human erythrocytes. Toxicon. 2021 Aug;199:41-48. doi: 10.1016/j.toxicon.2021.05.013. Epub 2021 May 31.

(26) Alfhili MA*, Alsalmi E, Alsughayyir J, Aljedai A, Abudawood M, Basudan AM. Calcium-oxidative stress signaling axis is essential for eryptosis elicited by novel p53 agonist inauhzin. J Chemother. 2022 Jul;34(4):247-257. doi: 10.1080/1120009X.2021.1963616. Epub 2021 Aug 19.

(27) Alfhili MA*, Alamri H, Alsughayyir J, Basudan AM. Induction of hemolysis and eryptosis by occupational pollutant nickel chloride is mediated through calcium influx and p38 MAPK signaling. Int J Occup Med Environ Health. 2021 Aug 30:135747. doi: 10.13075/ijomeh.1896.01814. Online ahead of print.

(28) Alamri HS, Akiel MA, Alghassab TS, Alfhili MA, Alrfaei BM, Aljumaa M, Barhoumi T. Erythritol Modulates Polarization of Macrophages: Potential Role of Tumor Necrosis Factor-α and Akt Pathway. J Food Biochem. 2021 Dec 19;e13960. doi: 10.1111/jfbc.13960. Online ahead of print.

(29) Alfhili MA*, Alsughayyir J, Basudan AM. Antiproliferative Wnt inhibitor wogonin prevents eryptosis following ionophoric challenge, hyperosmotic shock, oxidative stress, and metabolic deprivation. J Food Biochem. 2021 Nov;45(11):e13977. doi: 10.1111/jfbc.13977. Epub 2021 Oct 19.

(30) Alfhili MA*, Aljuraiban GS. Lauric acid, a dietary medium-chain fatty acid, elicits calcium-dependent eryptosis. Cells. 2021 Dec 1;10(12): 3388. doi: 10.3390/cells10123388.

(31) Alsughayyir J, Alshaiddi W, Alsubki R, Alshammary A, Basudan AM, Alfhili MA*. Geraniin inhibits whole blood IFN-γ and IL-6 and promotes IL-1β and IL-8, and stimulates calcium-dependent and sucrose-sensitive erythrocyte death. Toxicol Appl Pharmacol. 2022 Feb 1;436:115881. doi: 10.1016/j.taap.2022.115881. Epub 2022 Jan 10.

(32) Alfhili MA*, Basudan AM, Aljaser FS, Dera A, Alsughayyir J. Bioymifi, a novel mimetic of TNF-related apoptosis-induced ligand (TRAIL), stimulates eryptosis. Med Oncol. 2021 Oct 11;38(12):138. doi: 10.1007/s12032-021-01589-5.

(33) Alfhili MA*, Ahmad I, Alraey Y, Alangari A, Alqahtani T, Dera AA. Antibacterial and anti-virulence activity of hydroxynaphthoquinone plumbagin against multi-drug resistant clinical bacterial isolates. Saudi Med J. 2022 Nov;43(11):1224-1233. doi: 10.15537/smj.2022.43.11.20220446.

(34) Ghneim HK, Alfhili MA*, Alharbi SO, Alhusayni SM, Abudawood M, Aljaser FS, Al-Sheikh YA. Comprehensive investigations of key mitochondrial metabolic changes in senescent human fibroblasts. Korean J Physiol Pharmacol. 2022 Jul 1;26(4):263-275. doi: 10.4196/kjpp.2022.26.4.263.

(35) Ghneim HK, Alfhili MA*, Alharbi SO, Alhusayni SM, Abudawood M, Al-Sheikh YA. Biochemical and molecular assessment of selenium forms for the alleviation of oxidative stress in senescent human fibroblasts. Gen Physiol Biophys. 2022 Jul;41(4):309-318. doi: 10.4149/gpb_2022024.

(36) Alsughayyir J, Almalki Y, Alburayk I, Alalshaik M, Aljoni I, Kandel M, Alfhili MA*, Alabdullateef AA. Prevalence of transfusion-transmitted infections in Saudi Arabia blood donors: a nationwide, cross-sectional study. Saudi Med J. 2022 Dec;43(12):1363-1372. doi: 10.15537/smj.2022.43.12.20220634.       

(37) Alsughayyir J, Almalki Y, Alalshaik M, Aljoni I, Kandel M, Alfhili MA*, Alabdullateef A. Demography and blood donation trends in Saudi Arabia: A nationwide retrospective, cross-sectional study. Saudi J Biol Sci. 2022 Dec;29(12):103450. doi: 10.1016/j.sjbs.2022.103450. Epub 2022 Sep 16.

(38) Alfhili MA*, Basudan A, Alfaifi M, Awan ZA, Algethami MR, Alsughayyir J. Patterns of 25-Hydroxyvitamin D3, Calcium Status, and Anemia in the Saudi Population: A Cross-Sectional Study. Life (Basel). 2022 Dec 15;12(12):2119. doi: 10.3390/life12122119.

(39) Alfhili MA*, Alsughayyir J, Basudan A, Ghneim HK, Aboul-Soud MAM, Marie M, Dera A, Alfaifi M, Alkhathami AG, Awan ZA, Algethami MR, Al-Sheikh YA. Isolated and Combined Effects of Age and Gender on Neutrophil-Lymphocyte Ratio in the Hyperglycemic Saudi Population. Medicina (Kaunas). 2022 Aug 3;58(8):1040. doi: 10.3390/medicina58081040.

(40) Alfhili MA*, Alsughayyir J, Basudan A, Ghneim HK, Alfaifi M, Alamri HS, Awan ZA, Algethami MR. Patterns of Dyslipidemia in the Anemic and Nonanemic Hypertensive Saudi Population: A Cross-sectional Study. Int J Gen Med. 2022 Oct 21;15:7895-7906. doi: 10.2147/IJGM.S379597. eCollection 2022.

(41) Alsughayyir J, Basudan A, Alfaifi M, Awan ZA, Algethami MR, Al-Sheikh YA, Alfhili MA*. Association of Hyperglycemia with Reduced Rate of Anemia: A Population-based Study in Saudi Arabia. Saudi J Biol Sci. Under review.

(42) Kumar A, Alfhili MA, Bari A, Ennaji H, Ahamed M, Bourhia M, Chebaibi M, Benbacer L, Ghneim HK, Abudawood M, Alghamdi KM, Giesy JP, Al-Sheikh YA, Aboul-Soud MAM. Apoptosis-mediated anti-proliferative activity of Calligonum comosum against human breast cancer cells, and molecular docking of its major polyphenolics to Caspase-3. Front Cell Dev Biol. 2022 Oct 10;10:972111. doi: 10.3389/fcell.2022.972111. eCollection 2022.

(43) Aboul-Soud MAM, Ennaji H, Kumar A, Alfhili MA, Bari A, Ahamed M, Chebaibi M, Bourhia M, Khallouki F, Alghamdi KM, Giesy JP. Antioxidant, Antiproliferative Activity and Chemical Fingerprinting of Centaurea calcitrapa against Breast Cancer Cells and Molecular Docking of Caspase-3. Antioxidants (Basel). 2022 Aug 3;11(8):1514. doi: 10.3390/antiox11081514.

(44) Alfhili MA*, Alsughayyir J, Basudan A, Alfaifi M, Awan ZA, Algethami MR, Al-Sheikh YA. Reduced platelet-lymphocyte ratio in a Saudi population with impaired fasting glycemia and hyperglycemia. J King Saud Uni Sci. 2023 Jul;35(5):102699. doi: 10.1016/j.jksus.2023.102699. Epub 2023 Apr 28.

(45) Alfhili MA*, Alsughayyir J, Basudan A, Alfaifi M, Awan ZA, Algethami MR, Al-Sheikh YA. Blood indices of omega-3 and omega-6 polyunsaturated fatty acids are altered in hyperglycemia. Saudi J Biol Sci. 2023 Mar;30(3):103577. doi: 10.1016/j.sjbs.2023.103577. Epub 2023 Jan 27.

(46) Alfhili MA*; Alsughayyir J, Basudan AM, Alsubki R, Alqahtani S, Awan ZA, Algethami MR, Al-Sheikh, YA. Monocyte–Lymphocyte Ratio and Dysglycemia: A Retrospective, Cross-Sectional Study of the Saudi Population. Healthcare (Basel). 2022 Nov 15;10(11):2289. doi: 10.3390/healthcare10112289.

(47) Abudawood M, Alnuaim L, Tabassum H, Ghneim HK, Alfhili MA, Alanazi ST, Alenzi ND, Alsobaie S. An Insight into the Impact of Serum Tellurium, Thallium, Osmium and Antimony on the Antioxidant/Redox Status of PCOS Patients: A Comprehensive Study. Int J Mol Sci. 2023 Jan 30;24(3):2596. doi: 10.3390/ijms24032596.

(48) Alghareeb SA, Alfhili MA, Fatima S. Molecular Mechanisms and Pathophysiological Significance of Eryptosis. Int J Mol Sci. 2023 Mar 7;24(6):5079. doi: 10.3390/ijms24065079.

(49) Mir MA, Altuhami SA, Mondal S, Bashir N, Dera AA, Alfhili MA. Antibacterial and Antibiofilm Activities of β-Lapachone by Modulating the Catalase Enzyme. Antibiotics (Basel).2023 Mar 14;12(3):576. doi: 10.3390/antibiotics12030576.

(50) Nour AM, Badawi MA, Alfhili MA. Comment on: Prevalence of transfusion-transmitted infections in Saudi Arabia blood donors: A nationwide, cross-sectional study. Saudi Med J. 2023 Apr;44(4):421-422. doi: 10.15537/smj.2023.4.20230104.

(50) Aljuraiban GS, Alfhili MA, Aldhwayan MM, Aljazairy EA, Al-Musharaf S. Metagenomic Shotgun Sequencing Reveals Specific Human Gut Microbiota Associated with Insulin Resistance and Body Fat Distribution in Saudi Women. Biomolecules. 2023; 13(4):640. doi: 10.3390/biom13040640.   

(51) Aljuraiban GS, Alfhili MA, Aldhwayan MM, Aljazairy EA, Al-Musharaf S. Shared and Distinct Gut Microbial Profiles in Saudi Women with Metabolically Healthy and Unhealthy Obesity. Cell Mol Biol. 2023 May 29;11(6):1430. doi: 10.3390/microorganisms11061430.

(52) Alfhili MA*, Alsughayyir J. Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death. Xenobiotica. 2023 Aug 21:1-9. doi: 10.1080/00498254.2023.2248492. Online ahead of print.

(53) Alfhili MA*, Alotaibi GA, Alfaifi M, Almoghrabi Y, Alsughayyir J. Association of Platelet-Monocyte Ratio with Dyslipidemia in Saudi Arabia: A Large, Population-Based Study. Life (Basel). 2023 Aug 4;13(8):1685. doi: 10.3390/life13081685.

(54) Alshuweishi Y, Alfaifi M, Almoghrabi Y, Al-Sheikh YA, Alfhili MA*. A Retrospective Analysis of the Association of Neutrophil–Lymphocyte Ratio (NLR) with Anemia in the Saudi Population. Medicina. 2023 Sep 1; 59(9):1592. doi: 10.3390/medicina59091592.

(55) Alshuweishi Y, Alfaifi M, Almoghrabi Y, Alfhili MA*. AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study. Life (Basel). 2023 Sep 6; 13(9):1881. doi: 10.3390/life13091881.

(56) Alghareeb SA, Alsughayyir J, Alfhili MA*. Stimulation of Hemolysis and Eryptosis by α-Mangostin through Rac1 GTPase and Oxidative Injury in Human Red Blood Cells. Molecules. 2023 Sep 7; 28(18):6495. doi: 10.3390/molecules28186495.

(57) Alfhili MA*, Alyousef AM, Alsughayyir J. Tamoxifen induces eryptosis through calcium accumulation and oxidative stress. Med Oncol. 2023 Oct 17;40(11):333. doi: 10.1007/s12032-023-02205-4.

(58) Almuqrin A, Alshuweishi Y, Alfaifi M, Daghistani H, Al Sheikh YAA, Alfhili MA*. Prevalence and Association of Hyperuricemia with Liver Function in Saudi Arabia: A Large, Cross-Sectional Study. Ann Saudi Med. In print.

(59) Almuqrin A, Alshuweishi Y, Alfaifi M, Daghistani H, Alfhili MA*. Association of NLR, MLR, and PLR with hyperuricemia in the Saudi population: a large, cross-sectional study. Bratisl Lek Listy. In print.

(60) Basudan A, Basuwdan AM, Abudawood M, Farzan R, Alfhili MA. Comprehensive Retrospective Analysis of Colorectal Cancer Incidence Patterns in Saudi Arabia. Life (Basel). 2023 Nov 11;13(11):2198. doi: 10.3390/life13112198.

(61) Alshuweishi Y, Basudan A, Alfaifi M, Daghistani H, Alfhili MA*. Association of the HALP score with dyslipidemia: a large, nationwide retrospective study. Medicina (Kaunas). 2023 Nov 14;59(11):2002. doi: 10.3390/medicina59112002.

(62) Alghareeb SA, Alfhili MA, Alsughayyir J. Stimulation of Hemolysis and Eryptosis by β-caryophyllene oxide through CK1α, PKC, and MLKL stimulation. Life (Basel). 2023 Dec 4;13(12):2299. doi: 10.3390/life13122299.

(63) Alghareeb SA, Alsughayyir J, Alfhili MA*. Eriocitrin disrupts erythrocyte membrane asymmetry through oxidative stress and calcium signaling and activation of CK1α and Rac1 GTPase. Pharmaceuticals (Basel). 2023 Dec 2;16(12):1681. doi: 10.3390/ph16121681.

(64) Alghareeb SA, Alfhili MA, Alsughayyir J. Rosmarinic acid elicits calcium-dependent and sucrose-sensitive eryptosis and hemolysis through p38 MAPK, CK1α, and PKC. Molecules. 2023 Dec 12;28(24):8053. doi: 10.3390/molecules28248053.

(65) Alfhili MA*, Alsughayyir J. Bufalin reprograms erythrocyte lifespan through p38 MAPK and Rac1 GTPase. Toxicon.  2024 Feb 3;240:107636. doi: 10.1016/j.toxicon.2024.107636. Online ahead of print.

            (2) Book Chapters:

(1) Alfhili MA*, Lee MH. Flow Cytofluorometric Analysis of Molecular Mechanisms of Premature Red Blood Cell Death. Methods Mol Biol. 2021;2326:155-165. doi: 10.1007/978-1-0716-1514-0_11.


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بواسطة Mohammad Alfhili