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Dr. MIKHLID HAMMAD ALMUTAIRI د. مخلد بن حامد المطيري

Associate Professor

Faculty member in Molecular Genetics

كلية العلوم
College of Sciences No. 5, ground floor, Office No. AB 67
المنشورات
فرضية
1428

Toxic and Deformation Effects and the Cellular Genetics of the the anti-Jimston Drug for cancer of Experimental Mice "King Saud University"

ALMUTAIRI, MIKHLID . 1428

The present Research Project was conducted to examine the toxic, teratogenic and growth suppressing effects of gemcitabine on embryos obtained from treated female mice. The females were treated intra peritoneally with the drug at the dose levels of 0.625, 1.25 or 2.5 mg/kg body weight on days 6, 8, 10 or 12 of gestation. The project also aimed to follow up offspring of the treated mothers during the period extending from parturition up to six weeks of age. The follow up included body weight, toxicity, teratogenicity, growth suppressing effect and mortality rate. Moreover, it was planned to investigate the cytogenetical effects of the dose levels 0.625, 1.25 or 2.5 mg/kg on female mice after 12, 24 and 48 h from exposure. In the present Research Project, mature laboratory SWR/J mice aging 8-10 weeks and weighing 25.61-27.49 g were used. The mated animals were closely observed and the females were daily inspected for the presence of vaginal plugs and the date of plug detection was considered the zero date (D0) of gestation. Fetuses were examined on day 17 of pregnancy, and offspring were also examined at parturition and thereafter at weekly intervals up to 6 weeks of age. 

نوع عمل المنشور
Master Degree
مدينة النشر
Riyadh
نوع الفرضية
Master Thesis
المدرسة
Science
مزيد من المنشورات
publications

The tumor suppressor gene TP53 and its downstream genes P21 and MDM2 play crucial roles in combating DNA damage at the G1/S cell cycle checkpoint. Polymorphisms in these genes can lead to the…

بواسطة Mikhlid H. Almutairi , Bader O. Almutairi , Turki M. Alrubie, Sultan N. Alharbi, Narasimha R. Parine, Abdulwahed F. Alrefaei, Ibrahim Aldeailej, Abdullah Alamri, Abdelhabib Semlali
2021
publications

Background: Tumor suppresser gene (TP53) and its downstream genes (P21 and MDM2) play crucial roles in the regulation of DNA damage checkpoint (G1/S) of the cell cycle. Genetic polymorphisms in…

2019