Meta-analysis of clinical data using human meiotic genes identifies a novel cohort of highly restricted cancer-specific marker genes
McFarlane, Julia Feichtinger, Ibrahim Aldeailej, Rebecca Anderson, Mikhlid Almutairi, Ahmed Almatrafi, Naif Alsiwiehri, Keith Griffiths, Nicholas Stuart, Jane A. Wakeman, Lee Larcombe and Ramsay J. . 2012
Identifying cancer-specific biomarkers represents an ongoing challenge to the development of novel cancer diagnostic, prognostic and therapeutic strategies. Cancer/ testis (CT) genes are an important gene family with expression tightly restricted to the testis in normal individuals but which can also be activated in cancers. Here we develop a pipeline to identify new CT genes. We analysed and validated expression profiles of human meiotic genes in normal and cancerous tissue followed by meta-analyses of clinical data sets from a range of tumour types resulting in the identification of a large cohort of highly specific cancer biomarker genes, including the recombination hot spot activator PRDM9 and the meiotic cohesin genes SMC1beta and RAD21L. These genes not only provide excellent cancer biomarkers for diagnostics and prognostics, but may serve as oncogenes and have excellent drug targeting potential.
The tumor suppressor gene TP53 and its downstream genes P21 and MDM2 play crucial roles in combating DNA damage at the G1/S cell cycle checkpoint. Polymorphisms in these genes can lead to the…
Background: Tumor suppresser gene (TP53) and its downstream genes (P21 and MDM2) play crucial roles in the regulation of DNA damage checkpoint (G1/S) of the cell cycle. Genetic polymorphisms in…