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أ.د.ماجد بن صالح العقيل

Professor

وكيل كلية العلوم للتطوير والجودة

كلية العلوم
إدارة كلية العلوم - الدور الثاني مبنى 4
المنشورات
مقال فى مجلة
2020

Association of ANGPTL8 (Betatrophin) Gene Variants with Components of Metabolic Syndrome in Arab Adults..

NM., Alenad A, Alenezi MM, Alokail MS, Wani K, Mohammed AK, Alnaami AM, Sulimani M, Zargar S, Clerici M, Al-Daghri . 2020

Angiopoietin-like protein 8 (ANGPTL8) has a role in lipid metabolism, beta-cell proliferation and diabetes progression, however, the association between different variants in the ANGPTL8 gene and metabolic syndrome (MetS) components has not been studied widely especially in Arab ethnic groups. In this study, the associations of ANGPTL8 variants on MetS risk in Saudi Arab adults were investigated. A total of 905 unrelated Saudi adults (580 healthy controls and 325 MetS) were included. MetS was screened based on the International Diabetes Federation (IDF) criteria. The genotype and allele frequency distribution of rs737337 (T/C) and rs2278426 (C/T) polymorphism in ANGPTL8 gene was studied. Participants with MetS were significantly older, had higher BMI, and rs737337 polymorphism frequency was significantly lower than in control. Furthermore, the TC + CC genotype and C allele of rs737337 (T/C) was associated with decreased risk of hypercholesterolemia and hyperglycemia [odds ratio (OR) 0.61, 95%CI 0.40-0.93, p = 0.016 and OR 0.58, 0.39-0.86, p = 0.007 respectively for hypercholesterolemia; and OR 0.66, 0.45-0.97, p = 0.032 and OR 0.65, 0.46-0.93; p = 0.016 respectively for hyperglycemia]. Similarly, CT, CT + TT genotype and T allele of rs2278426 (C/T) were associated with decreased risk of hyperglycemia (p < 0.05). In conclusion, the study suggests that the gene variants in SNPs rs 737337 (T/C) and rs 2278426 (C/T) are associated with lower risk of hypercholesterolemia and hyperglycemia. These findings supplement the growing literature supporting the role of ANGPTL8 in lipid and glucose metabolism..

نوع عمل المنشور
Ppaer
رقم المجلد
Apr 21;10
رقم الانشاء
1
مجلة/صحيفة
Sci Rep
الصفحات
6764
مزيد من المنشورات
publications

Angiopoietin-like protein 8 (ANGPTL8) has a role in lipid metabolism, beta-cell proliferation and diabetes progression, however, the association between different variants in the ANGPTL8 gene and…

بواسطة Alenad A, Alenezi MM, Alokail MS, Wani K, Mohammed AK, Alnaami AM, Sulimani M, Zargar S, Clerici M, Al-Daghri NM.
2020
publications

Spexin (SPX) is a novel peptide thought to have a role in various metabolic regulations. Given its presumed body-weight regulatory functions, we aimed to determine whether lifestyle intervention…

بواسطة Al-Daghri NM, Wani K, Yakout SM, Al-Hazmi H, Amer OE, Hussain SD, Sabico S, Ansari MGA, Al-Musharaf S, Alenad AM, Alokail MS, Clerici M.
2019