Histomorphmetric Alterations Induced in the Testicular Tissues by Variable Sizes of
Male mice (BALB/C) were treated with SNPs (1mg/kg) using five different sizes (10, 20, 40, 60 and 100 nm) for 35 days. Testicular biopsies from all mice under study were subjected to histomorphological examinations.
RESULTS: Silver NPs (10 and 20 nm) had provoked morphometric changes in the testes of the subjected mice together with the following histological alterations: seminiferous tubules degeneration, spermatocytes cytoplasmic vacuolation, spermatocytes sloughing and spermatid giant cells formation. Larger SNPs (40, 60 and 100 nm) induced little or no
testicular histomorphometric alterations.
CONCLUSION: The findings of the present work may indicate that SNPs sub-chronic exposure could induce deleterious impacts on the testicular tissues and spermatogenic process that could affect fertility and reproduction, with smaller SNPs are more toxic than the larger ones.
Abstract: Tubulin is still a highly valued target in cancer chemotherapy. Agents that target tubulin
and microtubule dynamic are considered to be of high therapeutic potential. We conducted…
Silver nanoparticles (SNPs) are widely used in nanomedicine and consuming products with potential risk on human health.
:MalealbinoWistarratswereexposedto10nmgoldnanoparticlesatadoseof2000µg/kgtogetherwithor withoutpropolis(50mg/kg)for15consecutivedays. Freshrenalbiopsiesfromofallinvestigatedratswerecutrapidly,…