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Mohammed Nasser Alyemeni

Professor

Professor

كلية العلوم
Building 5 Floor G Office AB 43
المنشورات
مقال فى مجلة
2011

Evaluation of anti-diabetic activity and toxic potential of Lycium shawii in animal models

The powder and decoction of Lycium shawii Roem and Schult (Solonaceae) aerial part are used as a folklore remedy in the treatment of diabetes by the local community in various parts of Saudi Arabia. In the present study, attempts were made to scientifically justify the alleged anti-diabetic efficacy of this plant and to evaluate its toxic potential. The 80% ethanol extract of L. shawii aerial parts was prepared. After evaporation of ethanol, it was freeze dried. A statistically significant blood glucose lowering effect was noticed in Long-Evans rats treated orally with 250 mg/kg (P<0.05) and 500 mg/kg body weight (P<0.001) of L. shawii extract. In addition, there was a significant decrease in blood glucose levels of animals treated with the extract with a simultaneous load of glucose (2.5 mg/kg). A significant (P<0.001) anti-diabetic effect was also observed in streptozotocin (STZ) diabetic rats. The data obtained clearly justified the claimed hypoglycemic activity of L. shawii. To demonstrate any toxic potential of L. shawii treatment, acute (24 h) and chronic (90 days) toxicity studies were conducted using mice as experimental model. Acute dosages were 0.5, 1.0 and 3 g/kg body weight (gavage) while chronic dosage was 100 mg/kg per day of the extract in drinking water. All morphological, biochemical, haematological and spermatogenic changes, in addition to mortality, body weight changes and any change in vital organs were recorded and compared with the respective control groups. Histopathological investigations were done on vital organs and compared with the control mice without treatment. L. shawii chronic treatment induced changes in body weight, biochemical and hematological parameters and was found to possess significant spermatatoxic potential.
مجلة/صحيفة
JOURNAL OF MEDICINAL PLANTS RESEARCH
مزيد من المنشورات
publications

The fruits of eggplants have different shapes and sizes, which render them ideal for metabolic engineering. They can aid in increasing eggplant chlorogenic acid content, a critical nutrient. Among…

بواسطة Arpita Shankar, Prashant Kaushik, Mohammed Nasser Alyemeni, Saleh Alansi, Peerzada Yasir Yousuf
2023
تم النشر فى:
Journal of King Saud University-Science
publications

Soybean is a legume widely cultivated globally for its seeds, which are rich in oil and protein suitable for animal and human nutrition, and as a biofuel source. One of the main factors that…

بواسطة Breno Ricardo Serrão da Silva, Elaine Maria Silva Guedes Lobato, Leidy Alves dos Santos, Rodrigo Mendes Pereira, Bruno Lemos Batista, Mohammed Nasser Alyemeni, Parvaiz Ahmad, Allan Klynger da Silva Lobato
2023
تم النشر فى:
Agronomy
publications

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بواسطة Cengiz Kaya, Ferhat Ugurlar, Muhammed Ashraf, Mohammed Nasser Alyemeni, Michael Moustakas, Parvaiz Ahmad
2023
تم النشر فى:
Plants