تجاوز إلى المحتوى الرئيسي
User Image

Dr. Monirah A. Al-shaikh

Associate Professor

Associate Professor

كلية العلوم
Office No. 240 Third Floor Building No. 5 Science Building King Saud University
المنشورات
مقال فى مجلة
2017

Molecular docking and biological evaluation of some thioxoquinazolin‑4(3H)‑one derivatives as anticancer, antioxidant and anticonvulsant agents

Badshah, Danah S. Al‑Shamary, Monirah A. Al‑Alshaikh, Nabila Abdelshafy Kheder, Yahia Nasser Mabkhot and Syed Lal . 2017

Background: The quinazoline are an important class of medicinal compounds that possess a number of biological
activities like anticancer, anticonvulsant and antioxidant etc.
Results: We evaluated the previously synthesized quinazoline derivatives 1–3 for their anticancer activities against
three cancer cell lines (HepG2, MCF-7, and HCT-116). Among the tested compounds, quinazolines 1 and 3 were
found to be more potent than the standard drug Vinblastine against HepG2 and MCF-7 cell lines. All the tested compounds
had less antioxidant activity and did not exhibit any anticonvulsant activity. Also, molecular docking studies
were performed to get an insight into the binding modes of the compounds with human cyclin-dependent kinase 2,
butyrylcholinesterase enzyme, human gamma-aminobutyric acid receptor. These compounds showed better docking
properties with the CDK2 as compared to the other two enzymes.
Conclusions: The overall study showed that thioxoquinazolines are suitable antitumor agents and they should be
explored for other biological activities. Modification in the available lot of quinazoline and synthesis of its novel derivatives
is essential to explore the potential of this class of compounds. The increase in the threat and with the emergence
of drug resistance, it is important to explore and develop more efficacious drugs.

رقم المجلد
11
رقم الانشاء
48
مجلة/صحيفة
Chemistry Central Journal (Springer)
الصفحات
1-12
مزيد من المنشورات
publications

Abstract
Cancer is a broad category of disease that can affect virtually any organ or tissue in the body when abnormal cells grow
uncontrollably, invade surrounding tissue, and/or…

بواسطة Seham S. Alterary, Gamal A.E. Mostafa, Haitham Alrabiah, Monirah A. Al-Alshaikh, Maha F. El-Tohamy
2023
تم النشر فى:
Journal of Fluorescence
publications

3-(Adamantan-1-yl)-4-(4-fluorophenyl)-1-f[4-(2-methyoxyphenyl)piprazin-
1yl]-methylg-4,5-dihydro-1H-1,2,4-triazole-5-thione (AFT) was synthesized
and spectroscopic investigations have…

بواسطة Aamal A. Al-Mutairi, Y. Shyma Mary, Y. Sheena Mary, Sreejit Soman, Hanan M. Hassan, Monirah A. Al-Alshaikh & Ali A. El-Emam
2022
تم النشر فى:
Polycyclic Aromatic Compounds
publications

Nowadays, reverse osmosis is the most widely utilized strategy in membrane technology due to its continuous improvement. Recent studies have highlighted the importance of the surface…

بواسطة Seham S. Alterary, Raya M. Alyabes, Ahmed A. Alshahrani, and Monirah A. Al-Alshaikh.
2022
تم النشر فى:
Polymers