Syntheses and crystal structures of two adamantylsubstituted 1,2,4-triazole-5-thione N-Mannich bases
Garcia-Granda, Monirah A. Al-Alshaikh, Aamal A. Al-Mutairi, Hazem A. Ghabbour, Ali A. El-Emam,‡ Mohammed S. M. Abdelbaky and Santiago . 2017
In the title N-Mannich bases, 3-(adamantan-1-yl)-4-(4-fluorophenyl)-1-
[(4-phenylpiperazin-1-yl)methyl]-4,5-dihydro-1H-1,2,4-triazole-5-thione
(C29H34FN5S) (I), and 3-(adamantan-1-yl)-4-(4-fluorophenyl)-1-{[4-(2-methoxyphenyl)
piperazin-1-yl]-methyl}-4,5-dihydro-1H-1,2,4-triazole-5-thione
(C30H36FN5OS) (II), fluorophenyl, adamantane and piperazine moieties are
linked to a planar triazole ring. There is an additional phenyl ring on the
piperazine ring in (I) and a methoxyphenyl ring in (II). In compound (I), the
fluorophenyl and phenyl rings are inclined to the triazole ring by 86.55 (13) and
60.52 (12), respectively, and the two aryl rings are inclined to one another by
66.37 (13). In compound (II), the corresponding dihedral angles are 83.35 (13),
71.38 (15) and 11.97 (16), respectively. The crystal structure of (I) shows pairs
of C—H F hydrogen bonds forming inversion dimers, while in the crystal of
compound (II), in addition to the C—H F hydrogen bonds that generate
chains parallel to the b axis, there are C—H interactions present that link
the chains to form layers parallel to the ab plane.
Abstract
Cancer is a broad category of disease that can affect virtually any organ or tissue in the body when abnormal cells grow
uncontrollably, invade surrounding tissue, and/or…
3-(Adamantan-1-yl)-4-(4-fluorophenyl)-1-f[4-(2-methyoxyphenyl)piprazin-
1yl]-methylg-4,5-dihydro-1H-1,2,4-triazole-5-thione (AFT) was synthesized
and spectroscopic investigations have…
Nowadays, reverse osmosis is the most widely utilized strategy in membrane technology due to its continuous improvement. Recent studies have highlighted the importance of the surface…