Serum leptin and its relation to anthropometric measures of obesity in pre-diabetic Saudis

مقال فى مجلة

2007

تم النشر فى: https://pubmed.ncbi.nlm.nih.gov/17617917/

Kumar, Nasser M Al-Daghri 1, Omar S Al-Attas, Khalid Al-Rubeaan, Mehad Mohieldin, Mohammad Al-Katari, Alan F Jones, Sudhesh . 2007

 

Abstract

Background: Little information is available on leptin concentrations in individuals with IGT. This study aims to determine and correlate leptin levels to anthropometric measures of obesity in pre-diabetic, (IFG and IGT), type 2 diabetic and normoglycaemic Saudis.

Methods: 308 adult Saudis (healthy controls n = 80; pre-diabetes n = 86; Type 2 diabetes n = 142) participated. Anthropometric parameters were measured and fasting blood samples taken. Serum insulin was analysed, using a solid phase enzyme amplified sensitivity immunoassay and also leptin concentrations, using radio-immunoassay. The remaining blood parameters were determined using standard laboratory procedures.

Results: Leptin levels of diabetic and pre-diabetic men were higher than in normoglycaemic men (12.4 [3.2-72] vs 3.9 [0.8-20.0] ng/mL, (median [interquartile range], p = 0.0001). In females, leptin levels were significantly higher in pre-diabetic subjects (14.09 [2.8-44.4] ng/mL) than in normoglycaemic subjects (10.2 [0.25-34.8] ng/mL) (p = 0.046). After adjustment for BMI and gender, hip circumference was associated with log leptin (p = 0.006 with R2 = 0.086) among all subjects.

Conclusion: Leptin is associated with measures of adiposity, hip circumference in particular, in the non-diabetic state among Saudi subjects. The higher leptin level among diabetics and pre-diabetics is not related to differences in anthropometric measures of obesity.

• نوع عمل المنشور: PHD
• رقم المجلد: 6
• رقم الانشاء: 18
• مجلة/صحيفة: Cardiovasc Diabetol
• الصفحات: 1475-2840