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ناصر بن محمد بن ناصر الداغري

Professor

أستاذ الكيمياء الحيوية/مشرف كرسي المؤشرات الحيوية للأمراض المزمنة

كلية العلوم
2أ51 مبنى كلية العلوم رقم 5
المنشورات
مقال فى مجلة
2016

Hemisphere Asymmetry of Response to Pharmacologic Treatment in an Alzheimer's Disease Mouse Model

, Antigoni Manousopoulou 1 2, Satoshi Saito 3, Yumi Yamamoto 3, Nasser M Al-Daghri 4 5, Masafumi Ihara 6, Roxana O Carare 2, Spiros D Garbis . 2016

 

Abstract

The aim of this study was to examine hemisphere asymmetry of response to pharmacologic treatment in an Alzheimer's disease mouse model using cilostazol as a chemical stimulus. Eight-month-old mice were assigned to vehicle or cilostazol treatment for three months and hemispheres were analyzed using quantitative proteomics. Bioinformatics interpretation showed that following treatment, aggregation of blood platelets significantly decreased in the right hemisphere whereas neurodegeneration significantly decreased and synaptic transmission increased in the left hemisphere only. Our study provides novel evidence on cerebral laterality of pharmacologic activity, with important implications in deciphering regional pharmacodynamic effects of existing drugs thus uncovering novel hemisphere-specific therapeutic targets.

Keywords: Alzheimer’s disease; cilostazol; hemisphere asymmetry; mass spectrometry pharmacology; pharmacodynamics; pharmacoproteomics.

نوع عمل المنشور
PHD
رقم المجلد
51
رقم الانشاء
2
مجلة/صحيفة
J Alzheimers Dis
الصفحات
333-8
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