Influence of bone mineral density in circulating adipokines among postmenopausal Arab women

مقال فى مجلة

2020

تم النشر فى: https://pubmed.ncbi.nlm.nih.gov/31889860/

Al-Daghri, Mohammed Ghouse Ahmed Ansari 1, Syed Danish Hussain 1, Kaiser Ahmed Wani 1, Sobhy M Yakout 1, Dara Al-Disi 2, Majed S Alokail 1, Jean-Yves Reginster 1 3, Nasser M . 2020

 

Abstract

Osteoporosis and osteopenia has a significant link with substantial fracture risk. Epidemiological data revealed a protective role of adipose tissue on bone biology in postmenopausal osteoporosis. The current study assessed the associations between select adipokines and bone mineral density (BMD) in postmenopausal women. A total of 175 Saudi postmenopausal women were selected and categorized based on their BMD (normal & low-BMD). Circulating levels of select adipokines (adiponectin, resistin, leptin, and adipsin), insulin, 25(OH)D and RANKl were determined using commercially available assay kits. BMD was measured by dual-energy X-ray absorptiometry (DXA). Overall and among low-BMD subjects, adiponectin consistently showed a significant inverse association with BMD (overall -0.34, p < 0.01; low BMD group -0.34, p < 0.01). In multiple regression, adiponectin (-0.29 ± 0.06, p < 0.00) and resistin (-0.08 ± 0.04, p < 0.05) were inversely significant with BMD overall, but after stratification the significance was lost for resistin (-0.05 ± 0.04, p < 0.224) whereas adiponectin remained (-0.22 ± 0.07, p < 0.02) in low-BMD subjects. Adipsin, leptin and lipocalin-2 showed no significant associations. Findings of the present study revealed that only adiponectin showed a significantly strong inverse association with low BMD, suggesting that insulin sensitivity may influence bone health in Arab postmenopausal women.

Keywords: Adipocytokines; Osteoporosis/Osteopenia; Saudi postmenopausal women.

• نوع عمل المنشور: PHD
• رقم المجلد: 27
• رقم الانشاء: 1
• مجلة/صحيفة: Saudi J Biol Sci
• الصفحات: 374-379