Enhanced Ehrlich tumor inhibition using DOX-NP and gold nanoparticles loaded liposomes

Journal Article

, Mady MM, Fatima HA, Faridah FA, Amany AA, Mai A A and Ghannam MM. . 2015

• نوع عمل المنشور: Master
• المجلة \ الصحيفة: Pak. J. Pharm. Sci.
• رقم العدد: 6
• رقم الإصدار السنوي: 28 No.6 (Suppl.)
• الصفحات: 2321-2325

مستخلص المنشور

Treatment with doxorubicin (DOX) is a common treatment for different types of cancer. DOX-NP is one of a
well established marketed liposomal formulation for DOX. It has advantages over free DOX in reducing the cardiac
toxicity and increasing the efficacy. Gold nanoparticles (GNPs), have been widely used in biomedical applications such
as medical imaging and biosensors. Mice bearing Ehrlich tumor were injected with saline, free doxorubicin (DOX) in
solution, gold nanoparticles loaded liposomes and commercial liposomal encapsulated doxorubicin (DOX-NP). The
results showed that GNPs loaded liposomes could enhance the antitumor activity of commercial liposomal formulation
(DOX-NP) and displayed significantly decreased systemic toxicity compared with free DOX and commercial liposomal
formulation (DOX-NP) at the equivalent dose. So the injection of GNPs and DOX-NP is expected to increase the cell
killing and make it a promising approach to cancer treatment.