Insights into the strong in-vitro anticancer effects for bis(triphenylphosphane)iminium compounds having perchlorate, tetrafluoridoborate and bis(chlorido)argentate anions

Thesis

c,e,⁎⁎, Alessandra Folda a,1, Valeria Scalconb,1, Mohamed Ghazzali c, Mohammed H. Jaafar c, Rais Ahmad Khan c, Angela Casini d, Anna Citta a, Alberto Bindoli b, Maria Pia Rigobello a,⁎, Khalid Al-Farhan c, Ali Alsalme c, Jan Reedijk . 2016

• نوع عمل المنشور: paper
• رابط المنشور على الويب: Insights into the strong in-vitro anticancer effects for bis(triphenylphosphane)iminium compounds having perchlorate, tetrafluor

مستخلص المنشور

a b s t r a c t
Three new compounds containing the bis(triphenylphosphane)iminium cation (PPN+) with ClO4
−, BF4
− and
[AgCl2]− as counter anions have been synthesized and structurally characterized. The two derivatives with ClO4
−
and BF4
− were found to be isostructural by single crystal X-ray diffraction. Interestingly, the three compounds
show extremely potent antiproliferative effects against the human cancer cell line SKOV3. To gain insights into
the possible mechanisms of biological action, several intracellular targets have been considered. Thus, DNA binding
has been evaluated, as well as the effects of the compounds on the mitochondrial function. Furthermore, the compounds
have been tested as possible inhibitors of the seleno-enzyme thioredoxin reductase..