A highly sensitive and selective electrochemical determination of non-steroidal prostate anti-cancer drug Nilutamide based on ƒ-MWCNT in tablet and human blood serum sample

Journal Article

, 3. Karthik, R., R. Sasikumar, S.M. Chen, J. Vinoth Kumar, A. Elangovan, V. Muthuraj, P. Muthukrishnan, F.M.A. Al-Hemaid, M.A. Ali, M.S. Elshikh . 2017

• نوع عمل المنشور: Research Work
• رابط المنشور على الويب: A highly sensitive and selective electrochemical determination of non-steroidal prostate anti-cancer drug Nilutamide based on ƒ-
• المجلة \ الصحيفة: Journal of Colloid and Interface Science
• رقم العدد: 487
• رقم الإصدار السنوي: 2017
• الصفحات: 289–296

مستخلص المنشور

A novel electrochemical sensor based on the functionalized multiwalled carbon nanotube (f-MWCNT)
was successfully developed for the sensitive and selective determination of non-steroidal prostate
anti-cancer drug nilutamide in tablet and blood serum samples. The f-MWCNT was prepared by the simple
reflux method and characterized by the scanning electron microscopy (SEM), energy-dispersive X-ray
spectroscopy (EDX), Raman spectroscopy, X-ray powder diffraction (XRD) and fourier transform infrared
spectroscopy (FT-IR). Interestingly, the f-MWCNT was exhibited a superior electrocatalytic activity
towards the anti-cancer drug nilutamide when compared with pristine MWCNT and unmodified electrodes.
Besides, the electrochemical sensor was revealed an excellent current response for the determination
of nilutamide with wide linear ranges (0.01–21 lM and 28–535 lM), high sensitivity (11.023
and 1.412 lA lM1 cm2) and very low detection limit (LOD) 0.2 nM. The developed electrochemical sensor
was showed an excellent selectivity even in the presence of electrochemically active biological substances
and nitro aromatic compounds. Moreover, it manifested a good reproducibility and stability. In
addition, the f-MWCNT modified glassy carbon electrode (GCE) sensor was successfully applied for the
detection of nilutamide in tablet and blood serum sample.