Lack of Mitochondrial DNA Deletion(s) in Patients with Keratoconus​

Journal Article

Abu-Amero, Abdulrahman M. Al-Muammar​, Mohammed A. Gogandi, Khaled K. . 2015

• نوع عمل المنشور: Research
• المجلة \ الصحيفة: International Journal of Advances in Case Reports
• رقم العدد: 24
• رقم الإصدار السنوي: 2
• الصفحات: 1496-1499

مستخلص المنشور

Purpose to determine whether patients with Keratoconus and have evidence of mitochondrial DNA (mtDNA) deletions. Twenty seven Saudi Arabian patients with Keratoconus were recruited in this study. We compare their results to our database which contains mtDNA deletion information for 150 Saudi healthy controls free of systemic and ocular disease including Keratoconus. None of the Keratoconus patients screened had evidence of mtDNA deletion(s). mtDNA deletion(s) were not detected in any of the patients tested here. Other genetic or epigenetic factors cannot be excluded as a possible contributing factor to Keratoconus pathogenesis.
​Key words: Keratoconus, mitochondrial DNA