أستاذ مساعد | Assistant Professor

العنوان: 2A 89, Building 5, Department of Chemistry, College of Science, King Saud University, Riyadh | الهاتف: 99567

المواد الدراسية

CHEM 101
CHEM 499
المزيد

Dr. Rais Ahmad Khan

ACADEMIC PROFILE

Ph.D. Chemistry (2011)
Aligarh Muslim University, Aligarh, INDIA
Thesis Title: “PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES OF NEW METAL CHELATES”.
 
M.Sc. (Inorganic Chemistry) (2006)
Aligarh Muslim University, Aligarh, INDIA
Academic Grade: First Class
 
B.Sc. (Hons.) Chemistry (2004)
Aligarh Muslim University, Aligarh, INDIA
Academic Grade: First Class
 
TEACHING EXPERIENCE

 
Assistant Professor (Inorganic Chemistry) (Feb 2012 – till date) at Department of Chemistry, College of Science, King Saud University, Riyadh, KSA.
 
 
RESEARCH EXPERIENCE

 

  • Working in collaboration with Prof. Hongcai (Joe) Zhou (Texas A&M University, United State of America (2016 –till today).

 

  • Worked in collaboration with Prof. Jan Reedijk (University of Leiden, THE NETHERLANDS) and Prof. Angela Casini (Cardiff University, Cardiff, United Kingdom) (2012-2015)

 

  • Worked as Visiting Researcher (22nd July - 06th August 2015) in collaboration with Prof. Jan Reedijk and Prof. E. Bouwman at Metals and Catalysis, Biomimetics & Inorganic Materials (MCBIM), Leiden Institute of Chemistry, Gorlaeus Laboratories, University of Leiden, THE NETHERLANDS.

 

  • Worked as Visiting Researcher (June-August, 2013) in collaboration with Prof. Jan Reedijk and Prof. E. Bouwman at Metals and Catalysis, Biomimetics & Inorganic Materials (MCBIM), Leiden Institute of Chemistry, Gorlaeus Laboratories, University of Leiden, THE NETHERLANDS.

 

  • Worked as Young Researcher (April, 2009-March, 2010) on “Organometallic Synthesis of Biological Importance” under the collaboration of Prof. Claudio Pettinari and Prof. Fabio Marchetti, Department of Chemical Sciences, University of Camerino, ITALY.

 

  • Worked as Project Fellow (June, 2007- March 2009) on project entitled “Design Of Novel Anticancer Drugs And Analysis Of Their Therapeutic Potential By In Vitro And In Vivo Studies” sponsored by Department of Biotechnology, Ministry of Science and Technology, Government of India, in Department of Chemistry, Aligarh Muslim University in collaboration with Advanced Centre for Training and Education in Cancer, Mumbai, INDIA.

 
 
AWARD AND HONOR

 

  • Ongoing Awarded as Co-Principal Investigator (Co-PI) in the ongoing Major Research project of approx. 1.2 Million Saudi Riyal (SAR) funded by King Abdullah City of Science and Technology (KACST), (2015-17)
  • Ongoing Awarded as Co-Principal Investigator (Co-PI) in the ongoing Major Research project of approx. 1.5 Million Saudi Riyal (SAR) funded by National Project of Science and Technology (NPST), (2015-17)
  • Visiting Researcher, Institute of Chemistry, University of Leiden, The Netherland (2015)
  • Research Fellow on Project title "Design, synthesis, characterization, spectroscopic and biological properties of coordination compounds of transition metals and noble metals, held together by hydrogen bonding and or ligand bridging" funded by Distinguished Scientist Fellowship Program (DSFP) as under the guidance of Dr. Jan Reedijk (Emeritus Professor), Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands (2014-2015).
  • Research Fellow on Project title "Synthesis studies of coordination and organometallic compounds for new biologically-active, magnetic or luminescent materials" funded by Distinguished Scientist Fellowship Program (DSFP) as under the guidance of Dr. Jan Reedijk (Emeritus Professor), Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands (2013).
  • Visiting Researcher, Institute of Chemistry, University of Leiden, The Netherland (2013)
  • Scholarship for Ph.D. from University Grant Commission, Government of India (2010-11).
  • Awarded Young Researcher Fellowship from the University of Camerino, ITALY (2009-10).
  • Awarded Project Fellow in Major Research Project of Rs 53.45 Lacs funded by Department of Biotechnology, Ministry of Science and Technology, Government of India (2007-09).
  • Qualified Graduate Aptitude Test held at all India level (GATE-2006).

 
RESEARCH SKILLS

  1. Hands on Synthetic Chemistry:Azoles, carbohydrate, amino acids derived organic ligands with biological significance, their coordination compounds using various metal ions viz, CuII, CoII, ZnII, SnIV, CuI, AgI, RuIII, PtII and Organometallic compounds of Ruthenium using various arenes.
  2. Experience for the characterization of synthesized compounds: Using various spectroscopic techniques viz, Uv-Vis, FTIR, (1H, 13C, 31P, 119Sn, 195Pt) NMR, EPR (solid and liquid), FAB-MS, ESI-MS, Single X-ray Crystallography.
  3. Well-Acquainted with Biophysical Techniques for the Identification of biologically active compounds: DNA and Protein binding studies using Absorption Spectroscopy, Fluorescence Spectroscopy (viz, Ethidium Bromide Quenching Assay, Phosphate Binding Assay, Tryptophan Quenching Assay, Synchronous Fluorescence), Circular Dichroism, Gel Electrophoresis, Gel Documentation.

 
INSTRUMENT HANDLED

•        Spectroscopy      

  1. Electron Paramagnetic Resonance (EPR) Spectroscopy
  2. Fluorescence spectrophotometer
  3. Cyclic voltammetry
  4. FT-IR instrument
  5. Uv-visible spectrophotometer
  6. Viscosity measurements
  7. TGA/DSC Instrument

•        Chromatography

  1. High-Performance Liquid Chromatography (HPLC)
  2. High-Performance Thin-Layer Chromatography (HP-TLC)
  3. Thin Layer Chromatography (TLC)

•        Biophysical Techniques

  • Gel Electrophoresis of Protein and DNA
  • Gel Documentation

 
COMPUTER SKILLS                  

                                                 
 
Working knowledge of Windows, MS Office, ChemDraw, Corel Draw, Photoshop, Origin, Sigma plot.
 
 
 LIST OF PUBLICATIONS
 

  1. Nasser A. Al-Shabib, Fohad Mabood Husain, Faheem Ahmed, Rais Ahmad Khan, Iqbal Ahmad, Edreese Alsharaeh, Mohd Shahnawaz Khan, Afzal Hussain, Md Tabish Rehman, Mohammad Yusuf, Iftekhar Hassan, Javed Masood Khan, Ghulam Md Ashraf, Ali Mohammed Alsalme, Mohamed F. Al-Ajmi, Vadim V. Tarasov & Gjumrakch Aliev “Biogenic synthesis of Zinc oxide nanostructures from Nigella sativa seed: Prospective role as food packaging material inhibiting broad-spectrum quorum sensing”. Scientific Report, 6; 36761 (2016) (Impact Factor = 5.22) 

  2. Rais Ahmad Khan, Andreia de Almeida, Khalid Al-Farhan, Ali Alsalme, Angela Casini, Mohamed Ghazzali, and Jan Reedijk “First-row transition-metal norharmane compounds as possible cytotoxic agents: new insights based on a coordination chemistry perspective" Journal of Inorganic Biochemistry, 165; 128–135 (2016) (Impact Factor = 3.205)

  3. Rais Ahmad Khan, Fabian Dielmann, F. Ekkehardt  Hahn, Khalid Al-Farhan, Ali Alsalme, Xue Liu and Jan Reedijk “Tetrahedrally coordinated luminescent copper(I) compounds containing halide, phosphane and norharmane ligands”. Polyhedron, 111; 173-178 (2016) (Impact Factor = 2.108).

  4. Ali Alsalme, Sameen Laeeq, Sourabh Dwivedi, Mohd. Shahnawaz Khan, Javed Musarrat, Khalid Al-Farhan, Rais Ahmad Khan. “Synthesis, characterization of α-Amino acid Schiff base derived Ru/Pt complexes: induces cytotoxicity in HepG2 cell via protein binding and ROS generation.” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 163; 1-7 (2016) (Impact Factor = 2.653).

  5. Mohamed F. Al Ajmi, Afzal Hussain, Ali Alsalme, and Rais Ahmad Khan, “In vivo assessment of newly synthesized achiral copper(II) and zinc(II) complexes of benzimidazole derived scaffold as a potential analgesic, antipyretic and anti-inflammatory” RSC Advances, 6; 19475-19481  (2016) (Impact Factor = 3.289).

  6. Alessandra Folda, Valeria Scalcon, Mohamed Ghazzali, Mohammed H. Jaafar, Rais Ahmad Khan, Angela Casini, Anna Citta, Alberto Bindoli, Maria Pia Rigobello, Khalid Al-Farhan, Ali Alsalme and Jan Reedijk “Insights into the strong in-vitro anticancer effects for bis(triphenylphosphane)iminium compounds having perchlorate, tetrafluoridoborate and bis(chlorido)argentate anions” Journal of Inorganic Biochemistry, 153; 346–354 (2015) (Impact Factor = 3.205)

  7. Sartaj Tabassum, Ahmad Asim, Rais Ahmad Khan, Farukh Arjmand, Rajakumar Divya, Perumalsamy Balaji and Mohammad Abdulkader Akbarsha. " A multifunctional molecular entity CuII-SnIV heterobimetallic complex as potential cancer chemotherapeutic agents: DNA binding/cleavage, SOD mimetic, topoisomerase Iα inhibitory and in vitro cytotoxic activities" RSC Advances, 5; 47439–47450 (2015) (Impact Factor = 3.289)

  8. Imtiyaz Yousuf, Farukh Arjmand, Sartaj Tabassum, Loic Toupet, Rais Ahmad Khan, Maqsood A. Siddiqui, "Mechanistic insights of a novel chromone–appended Cu(II) anticancer drug entity: In vitro binding profile with DNA/RNA substrates and cytotoxic activity against MCF-7 and HepG2 cancer cells" Dalton transaction RSC, 44; 10330-10342 (2015) (Impact Factor = 4.177)

  9. Rais Ahmad Khan, Khalid Al-Farhan, Andreia de Almeida, Ali Alsalme, Angela Casini, Mohamed Ghazzali, Jan Reedijk, “Light-stable bis(norharmane)silver(I) compounds: Synthesis, characterization and antiproliferative effects in cancer cells.” Journal of Inorganic Biochemistry, 140; 1-5 (2014) (Impact Factor = 3.205).

  10. Rais Ahmad Khan, Farukh Arjmand, Sartaj Tabassum, Magda Monari, Fabio Marchetti, Claudio Pettinari, “Organometallic ruthenium(II) scorpionate as topo IIα inhibitor; in vitro binding studies with DNA, HPLC analysis and its anticancer activity.” Journal of Organometallic Chemistry, 771; 47-58 (2014) (Impact Factor = 2.336).

  11. Ali Alsalme, Mohamed Ghazzali, Rais Ahmad Khan, Khalid Al-Farhan, and Jan Reedijk. "A novel trinuclear μ3-hydroxido-bridged Cu(II) compound; a molecular cluster, stabilized by hydrogen bonding, bridging pyrazolates, terminal pyrazoles, water and nitrate anions. Polyhedron, 75; 64-67 (2014) (Impact Factor = 2.108).

  12. Rais Ahmad Khan, Shipra Yadav, Zahid Hussain, Farukh Arjmand and Sartaj Tabassum "Carbohydrate linked Organotin (IV) Complexes as Human Topoisomerase Iα inhibitor and their antiproliferative effects against human carcinoma cell line (Huh7) by transcriptional regulation of specific gene" Dalton Transaction RSC 43; 2534-2548. (2014) (Impact Factor = 4.177)

  13. Sartaj Tabassum, Ahmad Asim, Rais Ahmad Khan, Zahid Hussain and Farukh Arjmand. “Chiral Heterobimetallic Complexes Targeting Human DNA-Topoisomerase Iα.” Dalton Transaction, RSC 42; 16749-16761. (2013) (Impact Factor = 4.177)

  14.  Ali Alsalme, Khalid Al-Farhan, Mohamed Ghazzali, Miftahul Khair, Rais Ahmad Khan and Jan Reedijk. "Structure of bis(nitrato)tetrakis(pyrazole)cobalt(II): Fine tuning in the stabilisation of coordination entities by using intramolecular hydrogen bonding" Inorganic Chimica Acta, 407; 7-10. (2013) (Impact Factor = 1.918). 

  15. Avijit Sarkar, Alok Ranjan Paital, Rais Ahmad Khan, Farukh Arjmand, Valerio Bertolasi, Corine Mathoniere, Rodolphe Clérac and Debashis Ray." Ligand Dependent Self-Assembly of Hydroxido-Bridged Dicopper Units Templated by Sodium Ion" Dalton Transaction RSC, 42; 12495-12506. (2013) (Impact Factor = 4.177)

  16.  Rais Ahmad Khan, Ahmad Asim, Rita Kakkar, Deepti Gupta, Vivek Bagchi and Sartaj Tabassum. "Crystal Structure of heterobimetallic Ruthenium (II)-Tin(IV) complex; in vitro DNA Binding Studies with CT-DNA, Topo I Inhibition activity and DFT Calculations" Organometallics ACS, 32; 2546−2551. (2013) (Impact Factor = 4.186)

  17. Ashish Kumar Srivastava, Niraj Kumari, Rais Ahmad Khan, Richa Rai, Geeta Rai, Sartaj Tabassum and Lallan Mishra. "DNA cleavage activity and cytotoxicity of mononuclear and trinuclear Cu(II) complexes containing 1H-pyrazole-3,5-dicarboxylic acid as ligand" Indian Journal of Chemistry, Sec A, CSIR-NISCAIR, 52A, 835-844. (2013) (Impact Factor = 0.729)

  18. Sartaj Tabassum, Girish C. Sharma, Ahmad Asim, Ameer Azam and Rais Ahmad Khan. "Chiral Nano Heterobimetallic DNA Receptors: in vitro binding studies, cleavage activity and DNA condensation studies (TEM and AFM imaging)" Journal of Organometallic Chemistry, 713 123-133. (2012)  (Impact Factor = 2.336)

  19. Sartaj Tabassum, Mehtab Parveen, Akhtar Ali, Mahboob Alam, Anis Ahmad, Asad U Khan and Rais Ahmad Khan. "Synthesis of Novel Aryl-1,2,4,5-tetrazinane-3-thiones, in-vitro DNA Binding Studies, Nuclease Activity and its Antimicrobial activity" Journal of Molecular Structure, 1020; 33-40, (2012) (Impact Factor = 1.780)

  20. Sartaj Tabassum, Rais Ahmad Khan, Farukh Arjmand, Mubashira Aziz, Aarti S. Juvekar and Surekha M. Zingde "Glycoconjugate heterobimetallic complexes: synthesis, binding studies, nuclease activity, groove binding affinity and in-vitro cytotoxicity" Carbohydrate Research, 346; 2886–2895. (2011) (Impact Factor = 1.817)

  21. Ruchi Gaur, Rais Ahmad Khan, Sartaj Tabassum, Priyanka Shah, Mohammad I. Siddiqi and Lallan Mishra,"Interaction of a ruthenium(II)-chalcone complex with double stranded DNA: spectroscopic, molecular docking and nuclease properties" Journal of Photochemistry and Photobiology A: Chemistry, 220 145-152. (2011)  (Impact Factor = 2.477)

  22. Sartaj Tabassum, Rais Ahmad Khan, Farukh Arjmand, Subrata Sen, J. Kayal, Aarti S. Juvekar and Surekha M. Zingde. "Synthesis and characterization of glycoconjugate tin(IV) complexes: In vitro DNA binding studies, cytotoxicity, and cell death" Journal of Organometallic Chemistry, 696; 1600-1608 (2011) (Impact Factor = 2.336)

  23. Sartaj Tabassum, Rais Ahmad Khan, Farukh Arjmand, Aarti S. Juvekar and Surekha M. Zingde, "Synthesis of carbohydrate-conjugate heterobimetallic CuII-Sn2IV and ZnII-Sn2IV complexes; their interactions with CT DNA and nucleotides; DNA cleavage, in-vitro cytotoxicity" European Journal of Medicinal Chemistry, 45; 4797-4806, (2010) (Impact Factor = 3.902)

 
PAPERS PRESENTED/ CONTRIBUTED in CONFERENCES/ SYMPOSIUM/ WORKSHOPS

 

  1. Presented Paper “International Chemistry Conference” held on 08-10, November 2016 at King Saud University, Riyadh, Kingdom of Saudi Arabia.
  2. Paper contributed in IUPAC-2015, August 07-14 (2015) held at BEXCO, BUSAN, KOREA.
  3. Paper contributed in 12th European Biological Inorganic Chemistry Conference (EUROBIC-12) 24 - 28 August 2014, at Zurich, SWITZERLAND.
  4. Paper contributed in 41st International Conference on Coordination Chemistry (ICCC-41) 21 - 25 July 2014, at Suntec Singapore, SINGAPORE.
  5. Presented Paper in International Conference “Global Challenges- The Role of Chemistry in Giving their Solutions-ICC” held on 11-15th, June, 2011 at Bangkok, THAILAND.
  6. Presented Paper “International Conference on Chemistry; Frontier and Challenges- ICCFC” held on 05-06, March 2011 at Aligarh Muslim University, Aligarh, INDIA.
  7. Presented Paper in National Conference CRSI-RSC “Chemical Research Society of India and Royal Society of Chemistry” held 04-06, February 2011 at NISER-KIIT, Bhubaneswar, INDIA. 
  8. Presentation Paper in National Conference “Indian Council of Chemist-ICC” held on 19-21, December 2010 at Panjab University, Chandigarh, INDIA.
  9. Paper contributed in Gordon Research Conference, June 20-25 (2010). held at University of New England, Biddeford, USA.
  10. Presented Paper in International School of Organometallic Chemistry “ISOC” 7th Edition, 05-09, September, 2009 at the University of Camerino, ITALY.
  11. Presented Paper in an International Conference on “Interplay of Chemical and   Biological Science: Impact on Health and Environment-ISCBC” held on 04th March,   2009 at Delhi University, INDIA.
  12. Participated in “SERC” Summer School in Modeling and Informatics in Drug Design From 30th June to 18th July, 2008 organized by National Institute of Pharmaceutical Education and Research, Punjab, INDIA.
  13. Participated in Course on Polymer Characterization organized by the POLYCHAR World Forum on Advanced Materials sponsored by IUPAC, held on 14th February 2008 at India Institute of Technology (IIT), Delhi, INDIA.

 
 
COUNTRY VISITED FOR RESEARCH

 

  • UNIVERSITY OF LEIDEN, NETHERLANDS (EUROPE) (2015).
  • UNIVERSITYOF LEIDEN, NETHERLANDS (EUROPE) (2013).
  • UNIVERSITY  OF CAMERINO, ITALY (EUROPE) (2009-10).

 

المؤهلات العلمية

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