Synthesis and anti-candidal activity of some new pyrazoline derivatives.

Journal Article

Khan, Mashooq Ahmad Bhat, Abdul Arif Khan, Mohamed A. Al-Omar, Azmat Ali . 2017

• نوع عمل المنشور: Research

مستخلص المنشور

New pyrazoline derivatives were synthesized via the reaction of chalcones with cyclohexyl/phenyl
thiosemicarbazide in presence of ethanol and acetic acid. All the compounds were confirmed by FT IR,
1H NMR, 13C NMR and MS spectral data. The compounds (1-11) were evaluated for antifungal activity
against various strains of Candida species and compared with standard drug Itraconazole. MIC50 values
were found to be within the range of 41.099-127.895 μg/ml and MIC90 values were found to be within the
range of 62.121-240.955 μg/ml. Compound 7 was found to be most potent antifungal agent against
Candida strains. It appears that para-methoxy substitution at one phenyl ring and meta-methoxy
substitution at other phenyl ring of pyrazoline moiety made a significant contribution to the anti-
Candidal activity in this series of pyrazolines.