Mebeverine hydrochloride suppositories were prepared using Witepsol H15 suppository base. The effect of different concentrations of various enhancers (surfactants, amino acids and osmotic modifiers) on the drug release form the prepared suppositories was studied. The results showed that mebeverine hydrochloride suppositories containing Brij 35 (2%) and urea (10%) were superior to the other formulations containing the tested enhancers.

Mebeverine Hydrochloride (MB-HCl), an effective spasmolytic drug, was formulated as CODESTM. Colon-specific drug delivery technology CODESTM was designed to avoid the inherent problems associated with pH- or time-dependent systems.  Moreover, to achieve more protection and to control the drug release, MB-HCl was prepared as microspheres and compressed as the core tablet of CODESTM (modified CODESTM). The core tablet contained the drug in free form [formula 1 (F1)], or as microspheres with 2 different polymer : drug : lactulose ratios (1:1:0.5 [formula 2 (F2)] and 2:1:0.5 [formula 3 (F3)].