Design and synthesis of N-aryl-phthalimides as inhibitors of glucocorticoid-induced TNF receptor-related protein, pro-inflammatory mediators and cytokines in carrageenan-induced lung inflammation

N-Arylphthalimides (1−10P) derived from thalidomide
by insertion of hydrophobic groups were evaluated for
anti-inflammatory activity, and (4-(1,3-dioxo-1,3-dihydro-2Hisoindol-
2-yl)-N′-[(4-ethoxyphenyl)methylidene]benzohydrazide
6P was identified as a promising anti-inflammatory agent. Further
testing confirmed that compared with the control, 6P treatment
resulted in a considerable decrease in CD4+, NF-κB p65+, TNF-
α+, IL-6+, GITR+, and IL-17+ cell populations and an increase in

Preclinical pharmacokinetics, tissue distribution and excretion studies of a novel anti-candidal agent-thiosemicarbazide derivative of isoniazid (TSC-INH) by validated UPLC–MS/MS assay.

tA simple and sensitive UPLC–MS/MS assay was developed and validated for rapid determination ofthiosemicarbazide derivative of isoniazid (TSC-INH), a potent anti-candidal agent in rat plasma, tissues,urine and feces. All biological samples were prepared by protein precipitation method using celecoxib asan internal standard (IS). Chromatographic separation was achieved on Acquity BEHTMC18(50 × 2.1 mm,1.7 m) column using gradient mobile phase of acetonitrile and water (containing 0.1% formic acid)at flow rate of 0.3 mL/min.

Targeted nano-delivery of novel omega-3 conjugate against hepatocellular carcinoma: Regulating COX-2/bcl-2 expression in an animal model.

The present approach enumerates the effectiveness of tuftsin tagged nano-liposome for the cytosolic
transport of 2,6-di-isopropylphenol-linolenic acid conjugate against liver cancer in mice. Initially, the
conjugate in its free form was examined for anticancer potential on HepG2 liver cancer cells. Induction of
apoptosis and suppression of migration and adhesion of HepG2 cells confirmed the effectiveness of
conjugate as an anticancer agent. After this, role of the conjugate entrapped in a nano-carrier was

PHC 213: PHARMACEUTICAL ANALYTICAL CHEMISTRY

The course presents fundamental concepts and applications of volumetric analysis based on acid-base, precipitation, complexation and redox reaction. In addition on introduction to gravimetric analysis is given. 

ملحقات المادة الدراسية

PHC 523: Analytical Separation Methods

The course is designed to present different types of liquid chromatography with emphasis on High Performance Liquid Chromatography (HPLC) and recent advances in that area. Furthermore application of HPLC in the quantitation of pharmaceutical compounds is highlighted.

ملحقات المادة الدراسية

PHC 524: Spectroscopic Methods in Drug Analysis

The course deals with application of advanced methods in single- and multi-component spectrophotometric and spectrofluorimetric analysis of pharmaceutical compounds. Chemical derivatization and functional group analysis using colorimetric methods are also discussed

ملحقات المادة الدراسية

PHC 592: Seminar

In this course the student is required to prepare and orally presents a short review lecture on a selected specialized topic of current interest in the field of pharmaceutical chemistry. 

ملحقات المادة الدراسية

PHC 527: Chemical Kinetics in Drug Analysis

The course is tailored to introduce chemical kinetics on experimental and theoretical basis. Kinetic parameters involving order of reaction, rate constant, activation energy and related parameters will be presented. In addition, the use of kinetic methods in quantitation will be elaborated and the link between mechanism and reaction kinetic is highlighted. 

ملحقات المادة الدراسية

PHC 427: PHARMACEUTICAL INSTRUMENTAL ANALYTICAL CHEMISTRY

The course furnishes a broad basis for instrumental analysis which comprises, colorimetry, UV-spectrophotometry, fluorometry, IR-spectrometry, flame photometry, atomic absorption, spectrophotometry, polarimetry, refractometry, conductiometry and potentiometry. Furthermore, nuclear magnetic resonance (NMR), mass-spectrometry and high-performance liquid chromatography (HPLC) will be briefly introduced. 

ملحقات المادة الدراسية

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