tFor adequate cancer therapy, newer imaging modalities with more specific ligands for unique targetsare crucial. Underglycosylated mucin-1 (uMUC-1) antigen is an early marker of tumor development andis widely overexpressed on most tumors. A combination of nanotechnology with optical, radionuclide,and magnetic resonance (MR) imaging has great potential to improve cancer diagnosis and therapy. Inthis study, a multimodal nanoparticle imaging system was developed that can be used for optical, MRand positron emission tomography (PET) imaging.

Envisaging the role of Co in theranautics and biomedicine it is immensely important to evaluate its antimicrobial

activity. Hence in this study CoO thin nanosheets (CoO-TNs) were synthesized using wet chemical solution

method at a very low refluxing temperature (90 oC) and short time (60 min). Scanning electron microscopy of the grown

structure revealed microflowers (2~3 μm) composed of thin sheets petals (60~80 nm). The thickness of each individual

A dual fluorophore-based color-tunable molecular beacon visualized

the microRNA-294 expression-dependent color change in cells.

Objectives A special vector system was developed to

monitor the in vitro and in vivo endogenous level of a

primary transcript of miR124a during neuronal

differentiation

Results The upstream regions of miR124a were

fused with luciferase (Gluc) and their activity was

measured. During neurogenesis of P19 cells, the

primary transcript level of miR124a was increased

1.5-times compared to the undifferentiated P19 cells.

P19 cells grafted to nude mice exhibited the same

pattern of luciferase activity in vivo as they did

Studying gene expression profile in a single cancer cell is important because

multiple genes are associated with cancer development. Quantum dots (QDs) have been

utilized as biological probes for imaging and detection. QDs display specific optical and

electrical properties that depend on their size that can be applied for imaging and sensing

applications. In this study, simultaneous imaging of the cancer biomarkers, tenascin-C and

nucleolin, was performed using two types of aptamer-conjugated QDs. The simultaneous

Salmon sperm DNA was used as a blocking agent to reduce background

fluorescence signals from gelatin-coated cell culture dishes.