Breast cancer constitutes a major health problem for women worldwide. However, its incidence varies
between populations and geographical locations. These variations could be diet-related, since there are
several carcinogenic compounds in the modern diet, while natural products contain various anti-cancer
elements. Several lines of evidence indicate that, in addition to their clear preventive effect, these compounds
could also be used as therapeutic agents. In the present report we have shown that oleuropein, a

Breast cancer causes death due to distant metastases in which tumor cells produce matrix metalloproteinase
(MMP) enzymes which facilitate invasion. Oleuropein, the main olive oil polyphenol, has anti-proliferative effects.
This study aimed to investigate the effect of oleuropein on the metastatic and anti-metastatic gene expression in
the MDA human breast cancer cell line. We evaluated the MMPs and TIMPs gene expression by semi-quantitative
reverse transcriptase polymerase chain reaction (RT-PCR) in treated and untreated cells. This study demonstrated

Kefiran is a functional fermented milk product traditionally used for its beneficial probiotic properties. It exhibits antimicrobial, antioxidant, anti-inflammatory anticancer and different health promoting characteristics. Although kefiran showed potential effects against many cancer cell lines, little information is present in the literature on its effect against cervical and hepatocellular carcinoma as well as on zebrafish embryos.

We here in report the anti-cancer and kinases inhibitor activities of some substituted indole derivatives 1-10. which were synthesized and evaluated as analgesic and anticonvulsant agents before. Ten compounds were conveniently screened for their in vitro cytoyoxicity against a wide rannge of cell lines; these compounds showed potent activities against ovarian and breast cancer cell lines. The in vivo antiovrian cancer and anti-breast cancer of the most active in vitro compounds were estimated and founded highly potent.

Phytotherapy has a promising future in the management of diabetes, considered to be less toxic and free from
side effects as compared to the use of synthetic drugs. The aim of the present study was to assess the antidiabetic
possible of orally administered aqueous extracts of Murraya koenigii (ML) and Olea europaea (OL) leaves (100 and 200
mg/kg doses), in streptozotocin (70 mg/kg) induced diabetic rats. Metformin was used as a standard drug. Blood glucose,