A Bioinformatics Approach for In Vivo Imaging of Endogenous MicroRNA Targets During Neurogenesis

MicroRNAs (miRNAs), a class of small non-coding RNAs, have been reported to be functionally

involved with cellular metabolism and a variety of diseases. The importance of miRNA expression and functional

targeting has recently become a focus of intense research. However, their endogenous molecular targets have not

been clearly identified despite multiple attempts in prior studies using bioinformatics. Our bioinformatics strategy

and in vitro validation by the PCR, identified 16 out of 337 miR124a-predicted targets and 5 out of 299 miR9*-predicted

Intracellular Trafficking and Uptake of Hyaluronan-Doxorubicin Conjugates in Vitro

The purpose of this study was to determine the mechanism of uptake and release of doxorubicin from HA nanoparticle. We used human head and neck squamous cell carcinoma MDA-1986 as a model cell line. MDA-1986 was imaged after incubation with HA-DOX (NPs), doxorubicin, HA-CY7 or HA-DOX-CY7 at 15 minutes, 1, 6, 24, and 48 hours' time points using an inverted fluorescence microscope.

Revealing the History of Sheep Domestication Using Retrovirus Integrations

The domestication of livestock represented a crucial step in human history. By using endogenous

retroviruses as genetic markers, we found that sheep differentiated on the basis of their “retrotype”

and morphological traits dispersed across Eurasia and Africa via separate migratory episodes.

Relicts of the first migrations include the Mouflon, as well as breeds previously recognized as

“primitive” on the basis of their morphology, such as the Orkney, Soay, and the Nordic short-tailed

A Compound Class of Geometric and Lifetimes Distributions

A new lifetime class with decreasing failure rateis introduced by compounding truncated Geometric distribution and any proper continuous lifetime distribution. The properties of the proposed class are discussed, including a formal proof of its probability density function, distribution function and explicit algebraic formulae for its reliability and failure rate functions. A simple EM-type algorithm for iteratively computing maximum likelihood estimates is presented.

New family of logarithmic lifetime distribution

In this study a new lifetime class with decreasing failure rate is introduced by compounding truncated logarithmic distribution with any proper continuous lifetime distribution. The properties of the proposed class are discussed, including a formal proof of itsprobability density function, distribution function and explicit algebraic formulae for its reliability and failure rate functions.

A compound class of Poisson and lifetime distribuions

A new lifetime class with decreasing failure rate which is obtained by compounding truncated Poisson 
distribution and a lifetime distribution, where the compounding procedure follows same way that was previously 
carried out by Adamidis and Loukas(1998). A general form of probability, distribution, survival and hazard rate 
functions as well as its properties will be presented for such a class. This new class of distributions generalizes 
several distributions which have been introduced and studied in the literature. 

An upper bound for the distribution function of a positive quadratic

In this paper the researchers are presenting an upper bound for the distribution function of quadratic forms in normal vector with mean zero and positive definite covariance matrix. They also will show that the new upper bound is more precise than the one introduced by Okamoto [4] and the one introduced by Siddiqui [5]. Theoretical Error bounds for both, the new and Okamoto upper bounds are derived in this paper.

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