Objectives: 1) To determine tooth size ratios in Saudi subjects with Class II, Division 1 malocclusion, 2) to compare tooth size ratios between Saudi males and females and 3) to compare tooth size ratios between Saudi subjects with Class II, Division 1, and Saudi subjects with Class I normal occlusion, and Bolton’s results. Methods: The current study consisted of study models of sixty subjects (30 males and 30 females), aged 13 to 20 years. All subjects had Class II, Division 1 malocclusion.