In the present work, we undertake the preparation of chitosan nanofibers via electrospinning by varying solution concentration (1, 2, 3, 4 and 6 wt% (w/v)), applied voltage (14, 18 and 22 kV), flow rate (0.4 mL/h and 0.8 mL/h), needle diameter (0.2 mm and 0.8 mm) and distance between needle tip and collector (100 mm and 140 mm).

This study has developed a novel route for the synthesis of the thermoresponsive core-shell nanoparticles that consist of the magnetite core and the poly(N-isopropylacrylamide) (poly(NIPAAm) shell in aqueous medium. Magnetic nanoparticles (MNPs) were coated first with oleic acid (OA) and then vinyl carboxylic acid-β-cyclodextrin (MAH-β-CD). The OA-MNPs and the MAH-β-CD-MNPs showed mono-dispersion in n-hexane and aqueous medium, respectively.