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Omar Salem Abdullah Al-Attas

Professor

Biochemistry

كلية العلوم
Office NO:2A 59
المنشورات
مقال فى مجلة
2015
تم النشر فى:

Ultrastructural changes, increased oxidative stress, inflammation and alered cardiac hypertrophic gene expressions in heart tissues of rats exposed to incense smoke

, Al-Attas OS, Hussain T, Ahmed M, Al-Daghri N, Mohammed AA, De Rosas E, Gambhir D, Sumague TS. . 2015

Incense smoke exposure has recently been linked to cardiovascular disease risk, heart rate variability, and endothelial dysfunction. To test the possible underlying mechanisms, oxidative stress, and inflammatory markers, gene expressions of cardiac hypertrophic and xenobiotic-metabolizing enzymes and ultrastructural changes were measured, respectively, using standard, ELISA-based, real-time PCR, and transmission electron microscope procedures in heart tissues of Wistar rats after chronically exposing to Arabian incense. Malondialdehyde, tumor necrosis alpha (TNF)-α, and IL-4 levels were significantly increased, while catalase and glutathione levels were significantly declined in incense smoke-exposed rats. Incense smoke exposure also resulted in a significant increase in atrial natriuretic peptide, brain natriuretic peptide, β-myosin heavy chain, CYP1A1 and CYP1A2 messenger RNAs (mRNAs). Rats exposed to incense smoke displayed marked ultrastructural changes in heart muscle with distinct cardiac hypertrophy, which correlated with the augmented hypertrophic gene expression as well as markers of cardiac damage including creatine kinase-myocardial bound (CK-MB) and lactate dehydrogenase (LDH). Increased oxidative stress, inflammation, altered cardiac hypertrophic gene expression, tissue damage, and architectural changes in the heart may collectively contribute to increased cardiovascular disease risk in individuals exposed to incense smoke. Increased gene expressions of CYP1A1 and CYP1A2 may be instrumental in the incense smoke-induced oxidative stress and inflammation. Thus, incense smoke can be considered as a potential environmental pollutant and its long-term exposure may negatively impact human health.

نوع عمل المنشور
PHD
مجلة/صحيفة
Environ Sci Pollut Res
مزيد من المنشورات
publications

Abstract
Objectives: To assess circulating fetuin A and fetuin B levels in participants with and without Gestational Diabetes Mellitus (GDM) and to find out their correlations with other…

بواسطة Sobhy M Yakout 1, Samira Hussein 1, Omar S Al-Attas 1, Syed D Hussain 1, Gamal M Saadawy 1, Nasser M Al-Daghri 1
2023
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Abstract

بواسطة Kaiser Wani 1, Malak N K Khattak 1, Gamal M Saadawy 1, Omar S Al-Attas 1, Majed S Alokail 1, Nasser M Al-Daghri 1
2023
publications

Abstract

بواسطة Sobhy Yakout 1, Fatimah Faqeeh 1, Omar Al-Attas 1, Syed D Hussain 1, Nasser M Al-Daghri 1
2021