Assistant Professor | Assistant Professor of Nano-Biotechnology

Address: AA40, Nanobiotechnology and Molecular Biology lab, Department of Food Science and Nutrition

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VS. Periasamy

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Current Research Interests(English)
 
Food Nanotoxicology: Studying of In vitro nano-toxicological effects (adhesion, cell death/apoptosis, intracellular trafficking, oxidative stress related signaling and gene expression) of engineering-, food-, personal care-, cosmetic- and agricultural-related nanomaterials (both organic and inorganic) as well as safety issues of nanotechnology development and applications.
 
Human metagenomics: Cataloging of human gut microbial communities and role in the pathogenesis of chronic diseases (i.e., obesity, diabetes, colon cancer and asthma) in Saudi population: A comparative metagenomic analysis by next generation sequencing (NGS) platform.
 
Nanobiotechnology: Bio-prospecting, semi-synthesis and surface-functionalization of novel bio-materials (nano and micro super-structures) from biological resources (sugarcane waste, husk of rice, millet, sorghum, etc.), and screening for biomedical applications (drug delivery, 3D scaffolds, etc.,).

Drug Screening: To screening the mechanisms underlying the molecular therapeutic effect of phytochemicals, synthetic organic and inorganic compounds in cancer cells and to elucidate if the cell killing is brought about through apoptotic or non-apoptotic mechanisms.

Research Projects
 
 

Title of the Project Funding Agency Status & Cost
In vitro toxicity evaluation of food and agricultural related nanoparticles on human primary and established cells National Plan for Science, Technology and Innovation, KACST under MAARIFAH-1, Saudi Arabia
 		  Completed
2 Millions by AAAS peer review
Identification, characterization and in vitro evaluation of food surfactant associated-ultrafine carbonaceous particulates on human colon-, immune- and adult mesenchymal stem cells. National Plan for Science, Technology and Innovation, KACST under MAARIFAH-1, Saudi Arabia
 		 Highly recommended by AAAS peer review
2 Millions 
Profiling of human gut microbial communities and role in the pathogenesis of chronic diseases (obesity, diabetes, colon cancer and asthma) in Saudi population: A comparative metagenomic analysis by next generation sequencing platform.  (DSR-KSU-Highly cited Research group Project) On going
0.8 Million
Screening of human cell – nanoparticle interaction specific biomarkers for safety risk analysis of nanoscale-food additives National Plan for Science, Technology and Innovation, KACST under MAARIFAH-1, Saudi Arabia
 		 Recommended by AAAS peer review
2 Millions 
 

 
Patents
 

Title of the Patents Docket No. Status
A method of producing biogenic silica nanoparticles USA-32315.86 Filed
A novel antibacterial compound for multi & NBSP; drug resistant extended spectrum beta-lactamase producing bacterial pathogen causing respiratory tract infection from marine algae Ulva lactuca INDIA-3030/CHE/2014A Filed
Method for producing nobel metal Nano-composites USA-32315.85 Filed
Method of making three dimensional scaffold for three-dimensional cell culture USA-32315.84 Filed

 
 
Publications
2015

  1. Vaiyapuri Subbarayan Periasamy, Jegan Athinarayanan andAli A. Alshatwi. (2015) Aluminum oxide nanoparticles alter cell cycle progression through CCND1 and EGR1 gene expression in human mesenchymal stem cells. Biotechnology and Applied Biochemistry. DOI: 10.1002/bab.1368.
  2. Ali A. Alshatwi, Jegan Athinarayanan, Vaiyapuri Subbarayan Periasamy (2015) Green synthesis of bimetallic Au@Pt nanostructures and their application for proliferation inhibition and apoptosis induction in human cervical cancer cell. Journal of Materials Science: Materials in Medicine. 26:148
  3. Ravichandiran P, Athinarayanan J, Premnath D, Periasamy VS, Alshatwi AA, Vasanthkumar S. Synthesis, molecular docking and biological evaluation of novel 6-(4-(4-aminophenylsulfonyl)phenylamino)-5H-benzo[a]phenothiazin-5-one derivatives. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Mar 15;139:477-87
  4. Athinarayanan J, Alshatwi AA, Periasamy VS, Al-Warthan AA.Identification of Nanoscale Ingredients in Commercial Food Products and their Induction of Mitochondrially Mediated Cytotoxic Effects on Human Mesenchymal Stem Cells. J Food Sci. 2015 Feb;80(2):N459-64.
  5. Alshatwi AA, Athinarayanan J, Periasamy VS. Biocompatibility assessment of rice husk-derived biogenic silica nanoparticles for biomedical applications. Mater Sci Eng C Mater Biol Appl. 2015
  6. Periasamy VS, Athinarayanan J, Akbarsha MA, Alshatwi AA. Silica Nanoparticles Induced Metabolic Stress through  EGR1, CCND, and E2F1 Genes in Human Mesenchymal Stem Cells. Appl Biochem Biotechnol. 2015 Jan;175(2):1181-92.
  7. Periasamy VS, Athinarayanan J, Al-Hadi AM, Juhaimi FA, Mahmoud MH, Alshatwi AA. Identification of titanium dioxide nanoparticles in food products: Induce intracellular oxidative stress mediated by TNF and CYP1A genes in human lung fibroblast cells. Environ Toxicol Pharmacol. 2015 Jan;39(1):176-86.

2014

  1. Periasamy VS, Athinarayanan J, Al-Hadi AM, Juhaimi FA, Alshatwi AA. Effects of Titanium Dioxide Nanoparticles Isolated from Confectionery Products on the Metabolic Stress Pathway in Human Lung Fibroblast Cells. Arch Environ Contam Toxicol. 2014 [Epub ahead of print]
  2. Periasamy VS, Athinarayanan J, Alhazmi M, Alatiah KA, Alshatwi AA. Fe3O4 nanoparticle redox system modulation via cell-cycle progression and gene expression in human mesenchymal stem cells. Environ Toxicol. 2014 Dec 23.
  3. Jegan Athinarayanan, Vaiyapuri Subbarayan Periasamy, Mohammad Alhazmi, Khalid A Alatiah, Ali A Alshatwi.  (2014). Synthesis of biogenic silica Nanoparticles from rice Husks for biomedical applications. (In press). DOI: 10.1016/j.ceramint.2014.08.069.
  4. Ali A. Alshatwi, Jegan Athinarayanan and  Vaiyapuri Subbarayan Periasamy, Green Synthesis of Platinum Nanoparticles That Induce Cell Death and G2/M-Phase Cell Cycle Arrest in Human Cervical Cancer Cells, Journal of Materials Science: Materials in Medicine. (in print).
  5. Riyasdeen Anvarbatcha, Rajendran Senthilkumar, Periasamy Vaiapuri Subbarayan, Paul Preethy,   Suresh Srinag,   Mohammed Zeeshan,   Hanumanthappa Krishnamurthy,   Sankaralingam Arunachalamb and   Mohammad Abdulkader Akbarsha (2014). Antiproliferative and apoptosis-induction studies of metallosurfactant in human breast cancer cells MCF-7. RSC Advances, 10.1039/C4RA06702A (In Print)
  6. P. Ravichandiran, A. Jegan, D. Premnath, V. S. Periasamy and S. Vasanthkumar (2014). Design, synthesis, molecular docking as histone deacetylase (HDAC8) inhibitors, cytotoxicity and antibacterial evaluation of novel 6-(4-(4-aminophenylsulfonyl)phenylamino)-5H-benzo[a]phenoxazin-5-one derivatives. Medicinal Chemistry Research. DOI:10.1007/s00044-014-1129-3
  7. Jegan Athinarayanan, Vaiyapuri Subbarayan Periasamy and Ali A Alshatwi (2014) Biogenic Silica-Metal Phosphate (Metal = Ca, Fe or Zn) Nanocomposites: Fabrication From Rice Husk and Their Biomedical Applications. Journal of Materials Science: Materials in Medicine. 25(7):1637-44.
  8. Periasamy Vaiyapuri, Ali AAlshatwi, Mohammad AA, Kandhavelu J, Kandhavelu M. (2014) Time lapse microscopy observation of cellular structural changes and image analysis of drug treated cancer cells to characterize the cellular heterogeneity. Environ Toxicol. (In print) doi: 10.1002/tox.21950.
  9. Ravichandiran P, Jegan A, Premnath D, Periasamy VS, Muthusubramanian S, Vasanthkumar S. (2014). Synthesis, molecular docking and cytotoxicity evaluation of novel 2-(4-amino-benzosulfonyl)-5H-benzo[b]carbazole-6,11-dione derivatives as histone deacetylase (HDAC8) inhibitors. Bioorganic Chemistry. 53C:24-36. (In print).
  10. Athinarayanan J, Periasamy VS, Alsaif MA, Al-Warthan AA, Alshatwi AA. (2014)Presence of nanosilica (E551) in commercial food products: TNF-mediated oxidative stress and altered cell cycle progression in human lung fibroblast cells. Cell Biol Toxicol.  14. 30(2):89-100

2009 to 2013

  1. Alhazmi MI, Periasamy VS and Alshatwi AA (2013). Down-regulation of GST and CAT gene expression by methanolic extract of Nigella sativa seed in human peripheral blood mononuclear cells. African Journal of Biotechnology. 12(27), pp. 4364-4367.
  2. Ali A Alshatwi, V.S. Periasamy, Pandurangan Subash-Babu, Mohammed A. Alsaif, Abdulrahman A Alwarthan, Lei KA. 2013. CYP1A and POR gene mediated mitochondrial membrane damage induced by carbon nanoparticle in human mesenchymal stem cells. 2013. Environmental toxicology and pharmacology. 36(1):215-22.
  3. V.S. Periasamy and AA. Alshatwi. Tea polyphenols modulate antioxidant redox system on Cisplatin-induced ROS generation in a human breast cancer cell" 2013. Basic Clinical Pharmacology and Toxicology (in press). DOI: 10.1111/bcpt.12035.
  4. AA. Alshatwi, V.S. Periasamy, E. Ramesh, A.A. Al-Hazzani, M.A. Alsaif, A.A. Alwarthan.Al2O3 nanoparticles induce mitochondria-mediated cell death and upregulate the expression of signaling genes in human mesenchymal stem cells" 2012. Journal of Biochemical and Molecular Toxicology. 26 (11):469-476.
  5. AA. Alshatwi, V.S. Periasamy, E. Ramesh, A.A. Al-Hazzani, M.A. Alsaif, A.A. Alwarthan. Aluminum oxide nanoparticle induced mitochondrial mediated oxidative stress and altered the expression of antioxidant enzyme in human mesenchymal stem cells. Food additives contaminants: Part A. 2013. 30(1):1-10
  6. Ali A. Alshatwi, E. Ramesh, V.S. Periasamy, P. Subash-Babu. The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathways. Fundamental & Clinical Pharmacology. 2012. (Online). DOI: 10.1111/j.1472-8206.2012.01061.x
  7. Periasamy, V.S. Subash-Babu, P. Muthukumaran, V.R. Akbarsha, M.A. Alshatwi, A.A. In Vitro Cytotoxic Effect of Formulated Semecarpus Ghee Nanoemulsion on Human Cervical Cancer (SiHa) Cells. Advanced Science Letters, Volume 6 2012 , pp. 75-79(5).
  8. Venugopal Rajendiran, Mallayan Palaniandavar, Vaiyapuri Subbarayan Periasamy, Mohammad Abdulkader Akbarsha. New [Ru(5,6-dmp/3,4,7,8-tmp)2(diimine)]2 + complexes: Non-covalent DNA and protein binding, anticancer activity and fluorescent probes for nuclear and protein components. Journal of Inorganic Biochemistry. 2012: 116:151-62.
  9. Anvarbatcha Riyasdeen, Vaiyapuri S. Periasamy, Preethy Paul, Ali A. Alshatwi, and Mohammad A. Akbarsha (2011). Chloroform Extract of Rasagenthi Mezhugu, a Siddha Formulation, as an Evidence-Based Complementary and Alternative Medicine for HPV-Positive Cervical Cancers. (2012) Evidence-Based Complementary and Alternative Medicine. DOI:10.1155/2012/136527.
  10. Amal Al-Hazzani, Vaiyapuri Periyasamy, Pandurangan Subash-Babu and Ali A. Alshatwi (2011). Formulation of cashew nut shell liquid (CSNL) nanoemulsion, a potent inhibitor of human MCF-7 breast cancer cell proliferation. Medicinal Chemistry Research. 2012: 21(7): 1384-1388.
  11. Christo P Preethy, Ramamoorthy Padmapriya, Vaiyapuri S Periasamy, Anvarbatcha Riyasdeen, Suresh Srinag, Hanumanthappa Krishnamurthy, Ali A Alshatwi,, Mohammad A Akbarsha. (2011) Antiproliferative property of n-hexane and chloroform extracts of Anisomeles malabarica (L). R. Br. in HPV16-positive human cervical cancer cells. Journal of Pharmacology and Pharmacotherapeutics. 2012: 3(1):26-34.
  12. Ramakrishnan S, Palaniandavar M, Periasamy VS, Srinag BS, Krishnamurthy H,.Akbarsha MA. (2011). Ternary Dinuclear Copper(II) Complexes of a Hydroxybenzamide Ligand with Diimine Co-ligands: 5,6-dmp Ligand Enhances DNA Binding and Cleavage and Induces Apoptosis. Inorganic Chemistry. 50(14):6458-71
  13. Kumar RS, Periasamy VS, Preethy CP, Riyasdeen A, Arunachalam S,  Akbarsha MA. (2010) Cytotoxic effect of a polymer–copper(II) complex containing 2,2′-bipyridyl ligand on human lung cancer cells. Medicinal Chemistry Research. 20: 726 – 731.
  14. Rajendiran V, Palaniandavar M, Periasamy VS, Akbarsha MA. (2009). "[Ru(phen)2(dppz)]2+ as an efficient optical probe for staining nuclear components. J Inorg Biochem. 104: 217-220.
  15. Kumar RS, Arunachalam S, Periasamy VS, Preethy CP, Riyasdeen A, Akbarsha MA. (2009).Micellization Behaviour, DNA Binding, Antimicrobial, and Cytotoxicity Studies of Surfactant–Cobalt(III) Complexes Containing Di- and Tetramine Ligands. Aust. J. Chem. 62: 165–175
  16. Ramakrishnan S, Palaniandavar M, Rajendiran V, Periasamy VS, Srinag BS, Krishnamurthy H,.Akbarsha MA. (2009). Induction of Cell Death by DNA Binding and Cleaving Ternary Copper(II) Complexes of L-tyrosine and Diimines: Role of Co-ligands on Anticancer. Inorg Chem. 48 (4), 1309–1322.
  17. Kumar RS, Arunachalam S, Periasamy VS, Preethy CP, Riyasdeen A, Akbarsha MA. (2008). Surfactant-Cobalt(III) Complexes: Synthesis, CMC Determination, DNA Binding, Antimicrobial and Cytotoxic studies. J Inorg Biochem. 103:117-127.
  18. Rajendiran V, Murali M, Suresh E, Palaniandavar M, Periasamy VS, Akbarsha MA. (2008). Non-covalent DNA binding and cytotoxicity of certain mixed ligand ruthenium(II) complexes of 2,2’-dipyridylamine and diimines. Dalton Trans. 16:2157-70
  19. Kumar RS, Arunachalam S, Periasamy VS, Preethy CP, Riyasdeen A, Akbarsha MA. (2007). DNA binding and biological studies of some novel water-soluble polymer-copper(II)-phenanthroline complexes. Eur J Med Chem. 43(10): 2082-2091 
  20. Faisal K, Periasamy VS, Sahabudeen S, Radha A, Anandhi R, Akbarsha MA. (2008). Spermatotoxic effect of aflatoxin B1 in rat: extrusion of outer dense fibres and associated axonemal microtubule doublets of sperm flagellum. Reproduction. 135: 303–310
  21. Kumar RS, Arunachalam S, Periasamy VS, Preethy CP, Riyasdeen A, Akbarsha MA. (2008). Synthesis, DNA binding and antitumor activities of polymeric cobalt(III) complexes containing 1,10-phenanthroline ligand. Polyhedron. 27(3): 1111-1120.
  22. Rajendiran V, Karthik R, Palaniandavar M, Stoeckli-Evans H, Periasamy VS, Akbarsha MA, Srinag BS, Krishnamurthy H. (2007). Mixed-ligand copper(II)-phenolate complexes: effect of coligand on enhanced DNA and protein binding, DNA cleavage, and anticancer activity. Inorg Chem. 46(20): 8208-21.
  23. Faisal, K., Parveen, S., Rajendran, R., Girija, R., Periasamy, V.S., Kadalmani, B., Puratchikody, A., Ruckmani, K., Pereira, B.M.J., and Akbarsha, M.A. (2006) Male reproductive toxic effect of Quassia amara: Observations on mouse sperm. J. Endocrinol. Reprod., 10: 66-69.

 
 

 
SPECIAL TRAININGS

  1. January 2013 - European Molecular Biology Laboratory (EMBL) & European Bioinformatics Institute – “EBI-C-CAMB Next generation Genomics data analysis (NGS) workshop”.
  2. June, 2011 - European Molecular Biology Laboratory (EMBL) Heidelberg, Germany – Participant – Master course on “Target enrichment and next generation sequencing”
  3. September, 2010 – European Molecular Biology Laboratory (EMBL) Heidelberg, Germany – Advanced light microscopy Core facility – Visitor – A study on confocal microscopy & live imaging: Screening of methyl substituted Ruthenium complexes as intracellular fluorescent probes.
  4. September, 2010 – European Molecular biology laboratory (EMBL) Heidelberg, Germany –  Participant - Techniques for the generation of trangenic mice in theory and practice. – Eppendorf training center.
  5. July, 2008 - Institute of Bioinformatics and Applied Biotechnology, Bangalore, India "A Modular Course in Cheminformatics"
  6. January, 2008 – National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India – “The first hands – on Basic Flow Cytometry Course”. – Pande-Rath “First Prize winner”
  7. August, 2007 – Centre for Marine Science and Technology, MS University, Tamilnadu, India – EMBO World Practical Course on “DNA Microarray: Analysis and applications”.
  8. December 2005 Centre for Potential Genomic Sciences, Madurai Kamaraj University, Madurai , India– “National workshop on "Microarray Techniques”.
  9. January 2005 - PG Dept. of Zoology, Jamal Mohamed College, Tiruchirappalli, India “Workshop on Immunological techniques”.
  10. September 2004 - Dept. of Clinical Pharmacology, TN Medical College and BYL Nair Hospital, Mumbai, India – “5th ICMR Training Course on Clinical Pharmacology of Traditional Medicine”.
  11. August, 2004 - Dept. of Virology, King Institute of Preventive Medicine, Chennai, India “Workshop on Cell culture”.
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