Chlorogenic acid confers robust neuroprotection against arsenite toxicity in mice by reversing oxidative stress, inflammation, and apoptosis
Arsenic is a potent neurotoxic xenobiotic found in drinking water, and food. Chlorogenic acid (CGA), an
abundant polyphenol in coffee, potentially has a wide range of therapeutic benefits. This study aimed to explore
the mechanism in detail the neuroprotection provided by CGA against arsenite-induced toxicity in mice and the
underlying mechanisms involved. The mice were randomly divided into five groups; control, CGA (200 mg/kg),
arsenite (5 mg/kg), CGA (100 mg/kg) + arsenite, and CGA (200 mg/kg) + arsenite. All animals were treated
daily for four weeks. Arsenite exposure significantly lowered all brain functions (neurochemicals, AChE, and
BDNF) as well as cellular antioxidant activities, increased inflammatory and oxidative stress biomarkers, and the
antiapoptotic Bcl2 gene, and upregulated apoptotic Bax and Casp3 genes. Fortunately, CGA reversed all arseniteinduced
brain alterations in a dose-dependent manner. Therefore, CGA is recommended for practice use as a
natural safeguarding food additive.
Aedes aegypti (Culicidae), the mosquito that causes yellow fever, is regarded as a significant vector for
many disease agents. The current study sought to learn more about mosquito mid-gut…