Biotin-Bioconjugated Water-Soluble CdS Nanoparticles

Journal Article

, Al Terary, S.; Mangeney, C.; Brayner, R.; Antoun, T.; Fiévet, F.; Yassar, A . 2008

• نوع عمل المنشور: مقال علمي
• رابط المنشور على الويب: http://www.ingentaconnect.com/content/asp/senlet/2008/00000006/00000004/art00008
• الوسوم: Research Article
• المجلة \ الصحيفة: Sensor Letters, American Scientific Publishers
• رقم العدد: N⁰ 4
• رقم الإصدار السنوي: Vol. 6
• الصفحات: pp. 511-517

مستخلص المنشور

:Abstract

Semiconductor quantum dots (QDs) are a new generation of inorganic probes with advantageous properties over traditional organic probes for biological applications. A major hurdle in the use of QDs for biology is the inability of the hydrophobically synthesized QDs to interface with aqueous environments. Here we describe the synthesis of water-soluble CdS QDs end-capped with N-hydroxysuccinimide ester groups. These CdS QDs are synthesized in polyol medium using terthiophene dicarboxylic acid as a stabilizer. The carboxylic end groups are transformed into N-hydroxysuccinimidyl ester and are further cross-linked with biotin and avidin. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy results indicate successful modification of CdS QD surfaces.