Anti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) leaf extracts on streptozotocin induced diabetic rats
Al-Olayan, Maha El-Amin 1, Promy Virk, Mai Abdel Rahman Elobeid, Zainab Mohammed Almarhoon, Zeinab Korany Hassan, Sawsan Ali Omer, Nada Mohammed Merghani, Maha Hassan Daghestani, Ebtisam Mohammed . 2013
Phytotherapy has a promising future in the management of diabetes, considered to be less toxic and free from
side effects as compared to the use of synthetic drugs. The aim of the present study was to assess the antidiabetic
possible of orally administered aqueous extracts of Murraya koenigii (ML) and Olea europaea (OL) leaves (100 and 200
mg/kg doses), in streptozotocin (70 mg/kg) induced diabetic rats. Metformin was used as a standard drug. Blood glucose,
cholesterol, triglycerides, creatinine levels and body weight were estimated. ML and OL administration showed
significant decrease (p≥0.05) in cholesterol, triglyceride, and serum glucose levels (range 55.6%-64.6%) compared to the
metformin (62.7%); however, there was no significant effect on body weight and serum creatinine. Our results suggest
that both the ML and OL possess a potent antihyperglycemic and hypolipidemic effect, which may be due to the presence
of antioxidants such as carbazole alkaloids and polyphenols
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