Ameliorative effects of Embilica officinalis and Rosmarinus officinalis on cadmium-induced oxidative stress in Wistar rats

مستخلص المنشور: 

The study was designed to assess the antioxidative potential of three dietary antioxidants, vitamin C,
Rosemary (Rosmarinus officinalis) leaf extract (10% carnosic acid) and Amla (Embilica officinalis) fruit
extract (aqueous) on cadmium-induced oxidative stress and the related histopathology of the liver and
kidney of Wistar rats. Cadmium was administered as cadmium chloride (15 mg/kg body weight/day) for
4 weeks with five groups co-treated with the antioxidants, vitamin C (100 mg/kg/day) Rosemary leaf
extract (15 and 30 mg/kg/day) and amla fruit extract (100 and 200 mg/kg/day). The results showed that
cadmium induced a significant increase in both kidney and liver malondialdeyhde (MDA) levels coupled
with an inhibition of the superoxide dismutase (SOD) and catalase (CAT) activity. Co-treatment of
cadmium and the antioxidants did alleviate the oxidative stress which was observed as a significant
reduction in the MDA levels and an increase in the SOD activity both in the kidney and liver. CAT
activity was only increased by vitamin C and Rosemary (15 mg/kg) co-treatment in the kidney.
Furthermore, cadmium induced cellular disorganization of the kidney and liver was restored with the
co-treatment of the antioxidants being more pronounced with the plant extracts. Rosemary leaf extract
was efficacious at both the doses while the amla fruit extract had the most ameliorative effect at a
higher dose (200 mg/kg).

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