Antihyperglycemic Activity and Body weight effects of Extracts of Emblica officianalis, Tamarix nilotica and Cinnamon Plant in Diabetic Male Rats

مستخلص المنشور: 

The study investigated the anti-hyperglycemic potential of aqueous extracts of Emblica officianalis fruit, Tamarix nilotica leaf and cinnamon sticks for six weeks on sterptozotocin induced (70 mg/kg) diabetic obese rats compared to metformin as a standard drug. Six groups were administered plant extracts at two doses (200 mg/kg b.wt, 400mg/kg b.wt) with two groups
as the positive and negative controls. Blood glucose, body weights, cholesterol, triglycerides, and creatinine levels were assessed. All plant extracts doses; significantly (p≤0.001) reduced blood glucose levels among diabetic rats in the fifth and sixth weeks except the group treated with the lower dose of cinnamon. Body weights significantly increased during the fourth, fifth and sixth weeks, being more pronounced in the plant treated diabetic groups compared to the diabetic
control and metformin group. Furthermore, all doses showed significant decrease (p≥0.05) in serum glucose, cholesterol, triglyceride, and levels compared to the metformin, however, there was no significant serum creatinine effect. The anti-diabetic potential of the plant extracts usedwas dose-independent and there was no significant difference observed within the plant treated groups. However, all the plant extract used proved better than metformin. This suggests a
marked anti-diabetic potential of the plant extracts attributed to their polyphenolic constituents 

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