Pretubulysin, a Potent and Chemically Accessible Tubulysin Precursor from Angiococcus disciformis

Journal Article

• Magazine \ Newspaper: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• Issue Number: 24
• Volume Number: 48
• Pages: 4422-4425

Publication Abstract

Simplify, simplify, simplify! Pretubulysin (structure without the green substituents), a simplified tubulysin was prepared in the laboratory and also found in a natural myxobacterial source. This biosynthetic precursor of the tubulysins is not as active as tubulysins A and D but is still effective in picomolar concentrations against cancer cell lines.